天然煅烧骨修复材料(骼瑞)修复动物骨缺损的有效性研究  

The efficacy of calcined natural bovine bone( CBB) in the treatment of bone defects in animal

作　　者：何越 田智泉 王亮 姚阳 杨鹭 黄文涛 黄馨慧 

机构地区：[1]陕西瑞盛生物科技有限公司,西安710048 [2]西安组织工程与再生医学研究所

出　　处：《实用口腔医学杂志》2015年第2期167-170,共4页Journal of Practical Stomatology

摘　　要：目的:观察煅烧牛骨(骼瑞)修复动物骨缺损的有效性。方法:分别建立犬牙槽骨缺损修复模型、SD大鼠和新西兰白兔颅骨极限缺损模型,对照组骨缺损不植入修复材料,实验组骨缺损中植入骼瑞,每个组取材6只动物。术后用HE染色、Micro CT、Masson三色染色等方法观察缺损修复效果。结果:犬牙槽骨缺损修复8周后牙槽骨缺损修复良好。兔的颅骨修复实验中,实验组术后6周,煅烧骨颗粒周围有大量新骨形成。术后12周,骨缺损区新骨部分连接成片,已改建成板层骨,煅烧骨颗粒大多被新生骨包围。术后24周,新生骨成熟度进一步提高。SD大鼠颅骨缺损修复实验,术后8周,实验组骨缺损区域愈合,且填充修复区域的骨密度几乎接近于正常骨的骨密度。3种动物实验中,实验组骨缺损修复均优于对照组。结论:骼瑞材料对于骨缺损修复具有显著的促进作用。Objective：To observe the efficacy of calcined bovine bone（CBB）in the repair of animal bone defects.Methods：Ca-nine alveolar bone defect model,rat and rabbit calvarial critical size defect models were established respectively.All animals were randomly divided into 2 groups（n=6）.The defects in the experimental group were repaire with CBB,those in the control group were not treated.The effects were observed by HE staining,Micro CT and Masson trichrome staining.Results：Canin alveolar bone de-fects were well repaired 8 week after operation.The skull defects in rabbits and SD rats were replaced by new bone 1 2 and 8 weeks after operation respectively.In all the control groups bone defects were not healed or not completely repaired.Conclusion：CBB is ef-fective in the repair of bone defects.

关 键 词：煅烧牛骨(骼瑞) 牙槽骨缺损修复 颅骨极限缺损修复 

分 类 号：R783.1[医药卫生—口腔医学]