CXCL12/CXCR4在腺样囊性癌中的表达及对预后的价值  

Expression and the prognosis value of CXCL12/CXCR4 in adenoid cystic carcinoma

作　　者：黄应斌[1] 农晓琳[1] 杨亦萍[2] 曹阳[2] 李佳荃[3] 

机构地区：[1]广西医科大学口腔医学院口腔颌面外科,南宁530021 [2]广西医科大学口腔医学院病理科,南宁530021 [3]广西医科大学医学科学实验中心,南宁530021

出　　处：《实用口腔医学杂志》2015年第2期210-214,共5页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:30060082;81360404);教育部"春晖计划"科研启动基金(编号:教外司留[2003]593-7);广西自然科学基金重点项目(编号:2010GXNSFD013047);广西科学基金(编号:2013GXNSFAA019231)

摘　　要：目的:探讨CXCL12/CXCR4的表达与腺样囊性癌临床病理特征及预后的关系。方法:采用免疫组织化学SP法检测62例腺样囊性癌病理切片中CXCL12/CXCR4表达情况;Kaplan-Meier法、COX模型分析以上2个因子及临床病理相关指标对ACC患者预后生存时间的影响。结果:CXCL12、CXCR4在ACC组织中的阳性率分别是54.8%(34/62例)、77.42%(48/62例);Kaplan-Meier法结果显示CXCL12、CXCR4阳性组生存时间均较阴性组短(P<0.05);多因素结果分析显示CXCR4的表达、病理类型、临床分期、复发/转移是影响ACC预后的独立危险因素(P<0.05)。结论:CXCR4的表达与ACC的恶性程度有关;CXCR4表达、病理类型、临床分期、复发/转移为预测腺样囊性癌预后的重要指标。Objective：To investigate the expression of CXCL1 2 and CXCR4 in adenoid cystic carcinoma（ACC）and to explore its re-lationship with clinicopathologic characteristics and prognosis of the patients.Methods：The expression of CXCL1 2 and CXCR4 in af-fected tissue was detected immunohistochemically in 62 cases of ACC.Both of the two factors and clinicalpathology factors were pro-cessed in accordance with the Kaplan-Meier method and the COX regression model.Results：The positive rates of CXCL1 2 and CX-CR4 expression were 54.8%（34/62）and 77.42%（48/62）respectively.Patients with the 2 factor expression had a shorter survival time than those without them（P〈0.05）.Multivariate analysis revealed that CXCR4 expression,clinical stage,histological differentia-tion and metastasis/recurrence were independent risk factors for the prognosis of ACC patients.Conclusion：The expression of CXCR4 may be correlated with the malignancy of ACC.CXCR4 expression,clinical stage,metastasis/recurrence and histological differentia-tion can indicate the prognosis of ACC patients.

关 键 词：腺样囊性癌 CXCL12/CXCR4 侵袭 转移 临床预后 

分 类 号：R739.8[医药卫生—肿瘤]