氟伐他汀钠对舌鳞癌Tca8113细胞基质金属蛋白酶-9表达影响的研究  

The effect of fluvastatin sodium on MMP-9 expression in tongue squamous carcinoma Tca8113 cells

作　　者：乔光伟[1] 唐海萍[2] 景捷[1] 

机构地区：[1]宁夏医科大学总医院,银川750004 [2]宁夏医科大学口腔医学院

出　　处：《实用口腔医学杂志》2015年第2期262-265,共4页Journal of Practical Stomatology

摘　　要：目的:探讨氟伐他汀钠对舌鳞状细胞Tca8113细胞基质金属蛋白酶-9(MMP-9)表达的影响。方法:不同浓度氟伐他汀钠干预细胞24 h,用荧光免疫组织化学法、Western Blot检测细胞MMP-9蛋白表达,对数据进行统计学分析。结果:实验组细胞较对照组细胞中的MMP-9表达明显减少(P<0.05),各实验组间随着药物浓度增加蛋白表达递减。2种试验方法结果一致。结论:氟伐他汀钠可以抑制舌鳞状细胞癌细胞中MMP-9蛋白表达,且为浓度依赖性。Objective： To investigate the effect of fluvastatin sodium（FS） on MMP-9 expression in tongue squamous carcinoma Tca8113 cells. Methods： Immunofluoreseenee method and Western blot were used to detect the level of MMP-9 expression in Tca8113 cells treated by different concentration of FS for 24 h, the data were statistically analyzed. Results： MMP-9 expression in FS treated cells was significantly reduced（ P 〈 0.05 ） compared with control cells. With FS concentration increase the protein expression decreased in a dose-dependant manner detected by the 2 mothods. Conclusion： Fluvastatin Sodium can dose-dependantly inhibit the expression level of MMP-9 in TcaSll3 cells.

关 键 词：氟伐他汀钠(FS) 舌鳞状细胞癌 基质金属蛋白酶-9(MMP-9) 

分 类 号：R739.86[医药卫生—肿瘤]