卵巢上皮性癌中Notch-1和Jagged-1的表达及临床意义  

The expression and significance of Notch-1 and Jagged-1 in epithelial ovarian cancer( EOC)

作　　者：张秀青[1,2] 李万胜[3] 沈素朋[1] 邝钢[1] 董稚明[1] 

机构地区：[1]河北医科大学第四医院肿瘤研究所病理研究室,河北石家庄050011 [2]邯郸市中心医院生殖医学科,河北邯郸056001 [3]河北医科大学第四医院妇科,河北石家庄050011

出　　处：《现代肿瘤医学》2015年第7期977-980,共4页Journal of Modern Oncology

摘　　要：目的:检测Notch-1和Jagged-1基因蛋白在卵巢上皮性肿瘤中的表达,探讨二者在卵巢上皮性癌发生、发展、浸润、转移中的作用。方法:应用免疫组织化学(immunohistochemistry,IHC)方法检测75例卵巢上皮性癌和54例良性上皮性肿瘤中Notch-1和Jagged-1基因的蛋白表达情况,并分析其与临床病理特征之间的关系。结果:Notch-1和Jagged-1在卵巢上皮性癌组织中的表达明显高于良性上皮性肿瘤组织(P<0.01)。Notch-1和Jagged-1在卵巢上皮性癌中表达与组织分化程度有关,中低分化组的表达明显高于高分化组(P<0.05)。临床分期及有无淋巴结转移组中,二者的蛋白表达无明显差异(P>0.05)。在卵巢上皮性癌中两种蛋白表达呈明显正相关(r=0.295,P<0.05)。结论:Notch-1和Jagged-1可能与卵巢上皮性癌的发生及癌细胞的分化有关,且二者在其发生、发展过程中可能起协同作用。Objective： To detect the expression of Notch- 1 and Jagged- 1 in epithelial ovarian tumor and the effect of the two genes in the process of EOC formation,development,invasion and metastasis. Methods： Immunohistochemistry（ IHC） method was used to examine the expression of Notch- 1 and Jagged- 1 genes in 75 cases of EOC and 54 cases of benign epithelial tumors,to evaluate the relationship between the protein expression and clinical and pathologic characteristics. Results： The positive expression of Notch- 1 and Jagged- 1 in EOC was higher than them in benign epithelial tumors and the difference was highly significant（ P〈0. 01）. The expression of Notch- 1 and Jagged- 1 in EOC may be related with the tumor differentiation,the positive expression of them in Moderate and poor was higher than them in well（ P〈0. 05）. The difference of Notch- 1 and Jagged- 1 in clinical stage and lymph node status was not significant（ P〈0. 0 5）. The expression of the two genes was positively correlated（ r = 0. 295,P〈0. 05）. Conclusion： Notch- 1 and Jagged- 1 may be related with the oncogenesis,prognosis of EOC. They may play the synergetic effect in the process of EOC oncogenesis.

关 键 词：卵巢上皮性癌 免疫组织化学 NOTCH-1 JAGGED-1 

分 类 号：R737.31[医药卫生—肿瘤]