转录调节因子DEC2和肿瘤的研究进展  

A review of a transcriptional regulation factor DEC2 and tumor

作　　者：曹悦悦 吴雪琼[1,2,3] 赵思文[1,2,3] 范倩岩 马骥[1,2,3] 刘洋[1,2] 

机构地区：[1]中国医科大学基础医学院病理教研室,辽宁沈阳110001 [2]中国医科大学附属第一临床医院病理科,辽宁沈阳110001 [3]中国医科大学临床医学系

出　　处：《现代肿瘤医学》2015年第7期1002-1004,共3页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81302312);辽宁省教育厅科学研究一般项目(编号:L2013292);留学人员科技活动择优资助项目(编号:2013277)

摘　　要：DEC2(differentiated embryo-chondrocyte expressed gene 2)是一种碱性螺旋-环-螺旋(basic helix-loop-helix,b HLH)型转录抑制因子,通过识别靶基因启动子区域的E-box和N-box元件,从而发挥转录抑制功能。该基因于2001年首次被发现,并作为调节生物节律的重要成员被研究者所熟识。DEC2作为生物钟基因,在中枢主要定位于下丘脑视交叉上核。该基因的突变能显著缩短睡眠时间,而动物模型的结果也证实了这一观点。而最近发现该基因在周围组织中也有表达,DEC2的异常表达与多种生理和病理现象密切相关。随着科研人员的不断探索,发现该基因除了调节生物节律外,还参与调控免疫应答、细胞凋亡、缺氧应答、细胞分化、血管生成、肿瘤演进等多种生物学现象。本文将就其研究进展加以概述。DEC2（ differentiated embryo- chondrocyte expressed gene 2） is a basic helix- loop- helix transcriptional inhibitory factor,which can repress transcription of target gene through recognizing E- box and N- box element in promoter region. This gene was first discovered in 2001 and well known as biorhythm regulator. As biological clock gene,DEC2 located in hypothalamic suprachiasmatic nucleus（ SCN）. People thought DEC2 mutation can reduce hour of sleep greatly and animal test confirmed it. Recently,expression of DEC2 was also found in surrounding tissues. Its abnormal expression was closely connected with many physiological and pathological phenomena. With development of the study,people found other functions of DEC2 including regulating immune response,cell apoptosis,hypoxia response,cell differentiation,angiogenesis,tumor progression. This paper would briefly present a review of DEC2.

关 键 词：DEC2 转录因子 生物节律 缺氧 肿瘤 

分 类 号：R730[医药卫生—肿瘤]