节律性化疗在血液肿瘤治疗应用的研究进展  

Research progress of metronomic chemotherapy treatment in blood tumor

作　　者：艾工文[1] 孟秀琴[1] 

机构地区：[1]上海市第十人民医院血液内科,上海200072

出　　处：《现代肿瘤医学》2015年第7期1021-1024,共4页Journal of Modern Oncology

摘　　要：近几年发现某些化疗药物在低剂量、长时间接触中可选择性抑制血管内皮细胞的功能,且不受肿瘤细胞耐药状态的影响,与传统的最大耐受量化疗不同,主要是剂量低,间歇期短,能持续应用。本文对节律性化疗在血液病患者中的应用、作用机制、优势及其与其他治疗方法结合等方面的现状和前景进行综述。In recent years,we found that certain chemotherapy drugs in low dose and prolonged exposure could selectively inhibit vascular endothelial cell function,and not subject to the state of drug- resistant tumor cells,differ from conventional chemotherapy of the maximum tolerated dose mainly in low dose,short intermittent duration,and continuance to apply. In this essay,we reviewed the status quo and prospects of rhythmic chemotherapy in the application,mechanism,advantages and their combination with other treatment methods in patients of hematonosis.

关 键 词：节律性化疗 持续低剂量化疗 血液病 

分 类 号：R730.5[医药卫生—肿瘤]