CD146与泌尿系肿瘤关系的研究进展  

Current reasarch situation of correlation between CD146 and urological tumor

作　　者：袁红纲[1,2] 龙兵[1,2] 董自强[1,2] 张路生[1,2] 

机构地区：[1]宜昌市中心人民医院 [2]三峡大学第一临床医学院泌尿外科,湖北宜昌443003

出　　处：《现代肿瘤医学》2015年第8期1162-1165,共4页Journal of Modern Oncology

基　　金：湖北省宜昌市医疗卫生科技计划项目(编号:A08302-08)

摘　　要：CD146属于免疫球蛋白超家族(IGSF)成员,CD146的高表达与黑素瘤、前列腺癌等多种肿瘤发生及转移密切相关。然而,令人难以相信的是CD146在乳腺癌的表达与其他肿瘤的情况有所不同,其在乳腺癌中的表达明显降低,似乎提示CD146抑制乳腺的发生及进展。本文就CD146基因的结构、特征、功能及其泌尿系肿瘤的关系作一系统综述。CD146, also known as melanoma cell adhesion molecule （Mel -CAM, MCAM） or MUC18, belongs to the immunoglobulin superfamily（IGSF）. It promotes tumor progression of many cancers including melanoma and prostate. Strikingly,its expression is frequently lost in breast carcinoma cells, and it may act as a suppressor of breast cancer progression. This review aims to focus on the progress in understanding the signaling mechanisms and the functional relevance of CD146, a multifaceted molecule, and the correlation between CD146 and urological tumor.

关 键 词：CD146 免疫球蛋白超家族 泌尿系肿瘤 

分 类 号：R737.1[医药卫生—肿瘤]