大肠癌组织中TS和COX-2的表达及其与患者无病生存期的关系  

Relationship between the DFS and Expression of TS, COX-2 in Colorectal Cancer

作　　者：张高高[1,2] 郑国宝[1] 王仰坤[1] 原旭涛[1] 贠田[1] 蒙念龙 吕学霞[1] 

机构地区：[1]中国人民解放军第150中心医院,河南洛阳471000 [2]新乡医学院研究生院,河南新乡453000

出　　处：《现代生物医学进展》2015年第7期1297-1299,共3页Progress in Modern Biomedicine

基　　金：全军医药卫生科研基金项目(08Z006)

摘　　要：目的:探讨大肠癌患者癌组织中环氧化酶-2(COX-2)、胸苷酸合成酶(TS)的表达及其与患者无病生存期的关系。方法:筛选我院收治的大肠癌根治术患者,选择无病生存期大于48个月者30例和无病生存期小于48个月者29例。采用免疫组化法检测大肠癌组织中COX-2和TS的表达,并分析其与患者无病生存期的关系。结果:49例结直肠癌患者中,TS的阳性表达率为91.84%,COX-2的阳性表达率为77.55%。不同无病生存期的大肠癌患者TS的表达水平比较无统计学差异(P=0.646)。COX-2在无病生存期>48个月的患者癌组织中表达水平明显低于无病生存期<48个月的患者,差异有统计学意义(P=0.033)。结论:COX-2与大肠癌患者的无病生存期显著相关,可能成为预测大肠癌预后的参考指标。Objective： To investigate the correlation ofcyclooxygenase-2 （COX-2） and thymidylate synthase （TS） expressions in Cancerous tissue with the disease free survival of patients with coloreetal cancer. Methods： 30 patients with eolorectal cancer whose dis- ease-free survival were more than 48 months and 29 patients with colorectal cancer whose disease-free survival were less than 48 months were selected and underwent radical surgery in our hospital. The expression of COX-2 and TS in Cancerous tissue were detected by im- munohistochemistry, the relationship between them and disease-free survival were analyzed. Results： In 49 patients with colorectal can- cer, the positive expreesion rate of TS and COX-2 were 91.84% and 77.55%, respectivly. No significant difference was fotmd in the ex- pression of TS between the patients with different disease-free survival （P=0.646）. The expression of COX-2 of patients whose DFS were longer than 48 months were significantly lower than those whose DFS were shorter than 48 months （P=0.033）. Conclusion： COX-2 was significantly related to the disease-free survival of patients with colorectai cancer, which might be a marker to predict the prognosis of colorectal cancer.

关 键 词：环氧化酶-2 胸苷酸合成酶 无病生存期 大肠癌 

分 类 号：R735.34[医药卫生—肿瘤] R362[医药卫生—临床医学]