肾癌患者凝血指标的临床分析  

Clinical Analysis of Coagulation Indexes in Renal Cell Carcinoma Patients

作　　者：王志超[1] 戴洪双[1] 丁德鑫[1] 王文涛[1] 乔忠杰[1] 

机构地区：[1]哈尔滨医科大学附属第三医院泌尿外科,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2015年第7期1310-1312,1364,共4页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金项目(D200659);黑龙江省卫生厅科研课题(2006-185)

摘　　要：目的:探讨肾癌患者异常增高的凝血指标、静脉血栓栓塞症(VTE)发生率与临床分期的关系,分析肾癌患者血液高凝状态的临床特征。方法:对2010年至2012年335例住院的肾癌患者Fib、D-D、BPC水平进行检测并筛查发生VTE的患者。结果:335例肾癌患者中,异常Fib、D-D、BPC的发生率分别为20.6%、9.9%、6.6%,且随着肾癌分期的增加,凝血指标异常的发生率逐渐升高,各分期之间比较有统计学差异(P<0.05);VTE的发生率为2.2%,Ⅳ期肾癌患者最高为1.2%,且各分期之间比较有统计学意义(P<0.05)。年龄≥60岁、肿瘤最大径>10 cm、临床分期晚、伴有远处转移的肾癌患者血液高凝的发生率分别显著高于年龄<60岁、肿瘤最大径<10 cm、临床分期早、不伴有远处转移的肾癌患者(P<0.05)。结论:年龄≥60岁、肿瘤最大径>10 cm、临床分期晚、伴有远处转移可能是肾癌患者发生血液高凝状态和VTE的危险因素,应引起临床重视。Objective： To investigate the relationship between abnormal coagulation indexes, incidence rate of venous thromboembolism （VTE） and clinical stages of RCC patients and analyze the clinical features of RCC patients in hypercoagulable state. Methods： The coagulation index （Fib, D-D, BPC） of 355 RCC patients admitted from January 2010 to March 2012 in our hospital were deteced and the incidence of VTE was analyzed. Results： In 355 RCC patients, Fib, D-D, and BPC were abnormally high, the incidence rates of abnormally high Fib, D-D, and BPC levels were respectively 20.6%, 9.9%, and 6.6%. With the increase of stage, the incidence rate of abnormal coagulation indexes also significantly increased （P〈0.05）. The incidence of VTE was 2.2%, which was 1.2% of patients at Stage IV, and there was statistical difference between different stages （P〈0.05）. The incidence rates of hypercoagulability in RCC patients with age 〉 60 years, tumor size〉 10 cm, advanced stage, distant metastasis metastases were significantly higher than those RCC patients with aged 〈60 years, tumor size 〈10 cm, early stage and without distant metastasis（P〈0.05）. Conclusion： Age -〉 60 years, tumor size〉 10 cm, advanced stage, and distant metastasis may be the risk factors which lead to hypercoagulability and VTE in RCC patients and should be paid attention to.

关 键 词：肾癌 高凝状态 静脉血栓栓塞症 临床特征 

分 类 号：R737.11[医药卫生—肿瘤]