乳腺浸润性微乳头状癌的研究现状  

Advances in Research on Invasive Micropapillary Carcinoma of the Breast

作　　者：桃丽 张国强[1] 何川[1] 吴昊[1] 尹慧子 

机构地区：[1]哈尔滨医科大学附属肿瘤医院乳腺外科,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2015年第8期1585-1588,共4页Progress in Modern Biomedicine

摘　　要：乳腺浸润性微乳头状癌(IMPC)是乳腺浸润性癌的一种特殊类型,其发生率低,临床表现及影像学特征与普通的乳腺浸润性导管癌没有显著区别。这种病理类型可与普通浸润性导管癌混合出现,也可表现为单纯的浸润性微乳头状癌。但浸润性微乳头状癌具有独特的组织学形态及分子结构,决定了其病理学分级较高、易于发生淋巴结转移的侵袭性生物学行为特点。多数浸润性微乳头状癌在影像学上表现为边缘不清的不规则肿块影,常伴有微小钙化。其特征性病理形态为细胞膜上皮抗原(EMA)在肿瘤细胞簇外周的细胞和基质中腔隙边缘特异性染色,同时显微镜下瘤细胞表面发现微绒毛结构,说明了瘤细胞簇周围的空隙样结构实际上是管状腔隙,瘤细胞呈"极向倒转"方式排列。IMPC具有高度淋巴血管浸润倾向,局部复发率高,是一种预后较差的类型。本文对近年来关于乳腺浸润性微乳头状癌的研究进展进行了综述。Invasive micropapillary carcinoma of the breast（IMPC） is a relatively rare,distinct variant of invasive breast cancer.The clinical manifestations and imaging characteristics of IMPCs are not distinguishable from typical invasive ductal carcinoma. This characteristic pattern can be seen admixed with conventional ductal carcinoma or may present in its pure form. This tumor type has the distinctive histologic pattern and peculiar molecular features, which decide that this type is characterized by a high histologic grade,conspicuous propensity for lymphatic dissemination and an aggressive biological behavior. Most invasive micropapillary carcinomas of the breast presented as an irregular mass with a non-circumscribed margin associated with microcalcifications on imaging findings.Epithelial membrane antigen（EMA） typically stains peripheral cells of the tumor clusters as well as the borders of stromal spaces. This along with the ultrastructural finding of microvilli along the surface of cells suggests that the clear spaces are in fact the tubular lumina.This ＇ inside out growth pattern＇＇ is the pathological feature of IMPC. This type of breast carcinoma share a high propensity for angioinvasion and lymph node metastases and associated with high loco-regional recurrence rate and poor prognosis. This is a review about research progress of invasive micropapillary carcinoma of the breast in recent years.

关 键 词：乳腺癌 浸润性微乳头状癌 肿瘤 转移 

分 类 号：R737.9[医药卫生—肿瘤]