贞芪扶正颗粒对去甲氧柔红霉素联合阿糖胞苷方案治疗成人急性髓系白血病疗效及毒副反应的影响  

Effect of Zhenqifuzheng Granules on the Clinical Efficacy and Toxicity Reaction of Idarubicin and Cytarabine in the Treatment of Adult Acute Myeloid Leukemia

作　　者：姚蓓[1] 张引亮 陈旭昕 杨莉洁[1] 高山[1] 

机构地区：[1]第四军医大学西京医院血液内科,陕西西安710000 [2]陕西西安西电集团医院,陕西西安710000 [3]解放军海军总医院呼吸内科,北京100000

出　　处：《现代生物医学进展》2015年第9期1666-1670,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81300059;81170400)

摘　　要：目的：研究贞芪扶正颗粒对去甲氧柔红霉素联合阿糖胞苷方案治疗成人急性髓系白血病疗效及毒副反应的影响。方法：选取我院2006年2月~2012年8月期间收治的成人急性髓系白血病患者134例,并将其随机分为对照组与观察组。对照组采用去甲氧柔红霉素＋阿糖胞苷方案规范诱导缓解治疗,观察组在对照组治疗方案上加用贞芪扶正颗粒,观察和比较两组的临床疗效及不良反应的发生情况。结果：对照组与观察组的完全缓解率（CR）分别为73.2%（41/56）和79.5%（62/78）,中位OS分别为13.9个月和14.6个月,两组比较差异均无统计学意义（P〉0.05）。观察组III级以上的骨髓抑制现象的发生率显著低于对照组（P〈0.05）,粒细胞最低值显著高于对照组（P〈0.05）,粒细胞缺乏和血小板降低持续的总体时间均明显短于对照组（P〈0.05）;观察组各主要感染部位的发生率及感染总体发生率均显著低于对照组（P〈0.05）;观察组各种主要非血液学毒副反应包括呕吐、腹泻、肝毒性、肾毒性、神经毒性、心率失调、口腔炎症、皮疹及发热等的发生率显著低于对照组（73.1%vs.100%,P〈0.05）。结论：贞芪扶正颗粒能够有效改善去甲柔红霉素联合阿糖胞苷方案治疗成人急性髓系白血病的毒副反应,且不影响其临床疗效。Objective： To investigate the effect of Zhenqifuzheng granules on the clinical efficacy and adverse reactions of idarubicin and cytarabine in the treatment of adult acute myeloid leukemia. Methods： 134 cases of patients with acute myeloid leukemia admitted in our hospital from Febuary 2006 to August 2012 were randomly divided into the control group and observation group. The patients in control group were given idarubicin and cytarabine in order to reach remission, while the patients in observation were treated by the therapeutic schedule with zhenqi fuzheng granule. The clinical effect and incidence of adverse effects of patients were observed and compared between two groups. Results： The complete remission（CR） rate of control group and observation group were 73.2%（41/56） and 79.5%（62/78） respectively（P〉0.05）, the median overall survival（OS） were 13.9 and 14.6 months respectively（P〉0.05）. The incidence rates of grade III and higher grade bone marrow suppression, infection were all significantly lower in the observation group than those of the control group （P〈0.05）, the minimum of granulocyte was obviously higher than that of the control group （P〈0.05）, the duration of agranulocytosis and thrombocytopenia were both shorter in observation group （P〈0.05）. The incidence rate of non-hematology side effects such as vomiting, diarrhea, hepatotoxicity, nephrotoxicity, neurotoxicity, disorder of heart rates, rash, pyrexia and so on was significantly lower than that of the control group（73.1% vs. 100%, P〈0.05）. Conclusion： Zhenqi fuzheng granule could effectively reduce the side effect of idarubicin and cytarabine in the treatment of adult acute myeloid leukemia, but had little effect on the clinical efficacy.

关 键 词：贞芪扶正颗粒 去甲氧柔红霉素 阿糖胞苷 急性髓系白血病 毒副反应 

分 类 号：R733.7[医药卫生—肿瘤]