DNA损伤与眼病相关性的研究进展  

Research Progress in Eye Diseases Associated with DNA Damage

作　　者：刘玲华[1] 刘正[1] 杨明[1] 李伟军[1] 付小玻[1] 张晓梅[1] 

机构地区：[1]哈尔滨医科大学附属第一医院眼科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第11期2177-2180,共4页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅科学技术研究项目(11531179)

摘　　要：DNA损伤是复制过程中发生的DNA核苷酸序列永久性改变,并导致遗传特征改变的现象。对DNA损伤与修复的研究是现代分子生物学研究的热点之一。目前,DNA损伤对眼组织细胞凋亡、基因改变、细胞活性的影响已成为眼科疾病研究的热点。在年龄相关性白内障、老年性黄斑病变等眼科疾病的病因研究中证实氧化应激是其主要致病因素,当机体遭受有害刺激导致氧化应激时,机体、组织、细胞受到一系列损伤,而DNA的损伤对氧化应激最为敏感。本文就DNA损伤及其与晶状体上皮细胞及视网膜色素上皮细胞相关性的研究进展作一综述,为眼科疾病的研究以及防治提供新的方法及思路。DNA damage is a permanent change which occur during replication of DNA nucleotide sequence and it can result in genetic characteristics changes. The study of DNA damage and repair is one of the hot topics in the study of modem molecular biology.Currently, DNA damage has become a ophthalmic diseases hot research in eye tissue cells apoptosis, genetically modified, cell activity.In senile cataract, age-related macular degeneration and other eye disease etiology study confirmed that oxidative stress is the main pathogenic factors. However, when the body is stimulated by harmful factors which cause the oxidative stress, the body, tissues and cells will be injured, And the DNA damage of oxidative stress are the most sensitive. In this paper, DNA damage and its correlation with lens epithelial cells and retinal pigment epithelial cells research progress are reviewed, In order to provide new method and thought for the research and prevention of eye disease.

关 键 词：DNA损伤 修复 晶状体上皮细胞 视网膜色素上皮细胞 

分 类 号：Q75[生物学—分子生物学] R77[医药卫生—眼科]