肿瘤中与survivin有关的信号通路及分子以及靶向survivin的治疗前景  

Signaling Pathways and Moleculars Related with Survivin in Cancer and Prospects of Therapy Targeting Survivin

作　　者：祝丽双[1] 王浩[2] 刘畅[1] 陆慧琪[1] 韩焕兴[2] 

机构地区：[1]第二军医大学附属长征医院转化医学中心,上海200433 [2]第二军医大学附属长征医院眼科,上海200003

出　　处：《现代生物医学进展》2015年第11期2181-2184,共4页Progress in Modern Biomedicine

基　　金：国家科技部国际合作专项(OS2014ZR0042)

摘　　要：Survivin在细胞内环境稳定和肿瘤的形成中起重要的作用,在肿瘤的治疗中,survivivin的靶向治疗调节与一些典型的信号通路和一系列生长因子有关。众所周知,survivin是一个小的凋亡蛋白抑制因子,也是一个主要的抗癌靶标,与细胞分裂和凋亡抑制有关,它在大部分正常组织中缺失但在大部分癌组织中过表达。Survivin是一个与众多细胞信号通路有关的节点蛋白,这些通路协调各种细胞因子、转录网络和修饰基因,通过调节癌细胞内环境稳定直接或间接促进细胞增殖。临床前研究数据表明,survivin的抑制可以降低细胞增殖促进凋亡,增加细胞对细胞毒药物和放疗的敏感性,其过表达与不良预后和治疗耐受有关。因此对于癌症治疗,survivin是一个潜在的靶标。Survivin plays an important role in cell homeostasis and tumor formation. Survivin targeted therapy involved with some typical signaling pathways and a series of growth factors. As far as we know, survivin is an inhibitor of apoptosis proteins and anticancer target involved in cell division and apoptosis suppression. It is missing in most normal tissues but overexpression in most of the cancer tissues. Survivin is a node protein related to many cell signaling pathways, and these paths coordinate with each other and regulate a variety of cytokines, transcription networks and modification genes, and promote proliferation of cancer cells in a directly/indirectly way by adjusting the internal environment homeostasis. It has been revealed by some clinical research that： inhibition of survivin could supress cell proliferation and promote apoptosis, while increase cell sensitivity to cytotoxic drugs and radiotherapy. Survivin overexpression was related with poor prognosis and toleration to therapy. Therefore, survivin is a potential target for the treatment of cancer.

关 键 词：SURVIVIN 信号通路 靶向治疗 

分 类 号：R730.231[医药卫生—肿瘤] R730.5[医药卫生—临床医学]