卵巢癌中结缔组织生长因子的表达及其临床病理意义  

CTGF is a Novel Predictor of Metastasis in Ovarian Cancer

作　　者：张宗瑧 邵婷[1] 陈秀玮[1] 王树香[1] 刘天伯[1] 刘运铎[1] 

机构地区：[1]哈尔滨医科大学附属第三医院妇一科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2015年第12期2302-2306,共5页Progress in Modern Biomedicine

基　　金：黑龙江省科技厅自然科学基金面上项目(H201336;H1621)

摘　　要：目的:探讨卵巢癌中结缔组织生长因子(CTGF)的表达及其与卵巢癌临床病理特征的关系。方法:采用免疫组化法检测116例卵巢癌和25例正常卵巢组织中CTGF表达,并分析其与卵巢癌临床病理参数的关系。结果:正常卵巢组织及卵巢癌中CTGF的阳性表达率分别96%(24/25)、65%(75/116),卵巢癌中CTGF的阳性表达率显著低于正常卵巢组织(P<0.05)。CTGF的表达降低与卵巢癌患者的淋巴结转移、腹膜内转移及对化疗的敏感性显著相关(P<0.05);进一步的多因素Logistic回归分析显示CTGF的表达与卵巢癌腹膜转移(P=0.006,OR=4.185,95%CI=1.447-11.352)和淋巴结转移(P<0.001,OR=6.336,95%CI=2.563-15.972)均显著相关。结论:卵巢癌中CTGF的表达缺失,是卵巢癌腹膜转移和淋巴结转移的独立影响因素,可能作为预测卵巢癌转移的参考指标。Objective： To investigate the expression of CTGF expression and its correlation with clinicopathological characteristics of ovarian cancer. Methods： Immunohistochemistry was used to detect the expression of CTGF in 116 cases of ovarian cancer and 25 cases of normal ovarian tissue, and analyze the relationship between CTGF expression and clinicopathological characteristics of ovarian cancer. Results： The positive rate of CTGF expression in normal ovarian tissue and ovarian cancer were 96% （24/25） and 65% （75/116） respectively, which was significantly lower in the ovarian cancer than that of normal ovarian tissue. The decrease of CTGF expression was found to be associated with the lymph node metastasis, intraperitoneal metastasis and response to chemotherapy of ovarian cancer（P〈0.05）. Further multivariate logistic regression analysis showed that CTGF expression was significantly associated with the intraperitoneal metastasis of ovarian cance （P=-0.006, OR--4.185, 95% CI=1.447-11.352） and lymph node metastasis （P〈0.001, OR=6.336, 95% CI=2.563-15.972）. Conclusion： The loss of CTGF expression was independent influencing factor of lymph node metastasis and intraperitoneal metastasis of ovarian carcinoma, which may be used as an potential biomarker for the metastasis of ovary carcinoma.

关 键 词：结缔组织生长因子 卵巢癌 转移 

分 类 号：R737.33[医药卫生—肿瘤]