蛋白激酶与神经系统功能调控  

Protein kinases and the functional regulation in the nervous system:a review of illustration with examples

作　　者：曹帅[1,2] 王韵[1,2,3] 

机构地区：[1]北京大学基础医学院神经生物学系 [2]北京大学神经科学研究所教育部/卫生计生委重点实验室,北京100191 [3]北京大学麦戈文脑研究所,北京100871

出　　处：《生命科学》2015年第3期306-315,共10页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金杰出青年基金项目(30925015);国家自然科学基金重点项目(30830044);国家自然科学中加合作基金项目(91332119);国家重点基础研究发展计划(“973”项目)(2014CB542204)

摘　　要：翻译后的磷酸化修饰是蛋白质结构和功能的重要调节方式。催化蛋白质磷酸化过程的蛋白激酶广泛参与神经发育、感觉、学习记忆、情绪与认知等生理过程及神经退行性疾病、慢性疼痛及精神疾病等病理生理过程,是生命科学领域的研究热点。现将举例说明蛋白激酶在神经系统内的重要作用,并介绍以蛋白激酶为靶点的药物开发现况。Post-translational phosphorylation modification plays vital roles in modulating protein structure and function. Protein kinases, which catalyze the phosphorylation reaction of substrate protein, take part in most physiological neural processes such as sensory perception, learning and memory, emotion and cognition. Dysfunction of protein kinases leads to pathophysiological events, such as neurodegenerative disorders, chronic pain and psychiatric disorders. Examples would be taken to interpret how the kinases work in the nervous system, based on which kinase-targeted drugs are to be developed or under clinical trials for their clinical effects.

关 键 词：神经系统 蛋白激酶 CDK5 PKD1 LIMK 

分 类 号：Q42[生物学—神经生物学] Q555[生物学—生理学]