放射照射后牵张成骨下牙槽神经电生理变化的实验研究  

Experimental Study of Distraction Osteogenesis in the Irradiated Dog Mandible:the Electrophysiological Changes of IAN

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作  者:柳玉晓[1] 刘桂才[2] 朱国雄[1] 刘彦普[2] 

机构地区:[1]济南军区总医院口腔科,山东济南250031 [2]第四军医大学口腔医学院颌面外科

出  处:《口腔医学研究》2015年第3期230-233,共4页Journal of Oral Science Research

摘  要:目的:探讨放射照射后牵张成骨过程中下牙槽神经的电生理变化。方法:12只中国杂种犬随机分为A、B、C三组,A、B、C组为实验组,每组4只,单侧下颌A组接受总剂量22.8Gy,5.7Gy/4次/2周(相当于50Gy/25次/5周),B组接受总剂量24.8Gy,6.2Gy/4次/2周(相当于60Gy/30次/6周),C组接受总剂量27.2Gy,6.8Gy/4次/2周(相当于70Gy/35次/7周)的60 Co放射照射。放射照射完成后3个月时,各组分别于照射区下颌骨切开,置入牵张器。经五天延迟期,以0.5mm/次,2次/d的速度牵张下颌骨10d,然后固定8周。分别于放疗前、放疗结束后、牵张前、牵张第6天、牵张完成即时、固定第2,4,8周8个时间点以神经电生理检诊仪测定神经电生理变化。结果:50Gy和60Gy组牵张过程中动作电位呈现适应性变化,70Gy组不能完整导出动作电位。结论:低剂量放射照射不会单独对牵张过程中神经电生理变化造成影响,高剂量放射照射不能完成电生理检查。Objective: To explore the electrophysiological changes of IAN during DO after irradiation. Methods: 12 Chinese dogs were randomly divided into 3 groups--GroupA,B, C. Each group owned 4 dogs individually. GroupA received a unilateral irradiation from 60Co in the mandible with a total dose of 22.8Gy in four 5.7Gy fractions (e- quivalent to 50Gy/25 fractions) within two weeks. GroupB receieved a unilateral irradiation from 6o Co in the mandi- ble with a total dose of 24. 8Gy in four 6. 2Gy fractions (equivalent to 60Gy/30 fractions) within two weeks. GroupC receieved a unilateral irradiation from 60Co in the mandible with a total dose of 27.2Gy in four 6.8Gy frac- tions (equivalent to 70Gy/35 fractions) within two weeks. Bilateral coticotomy was made 3 months after completion of irradiation. After a 1--week latency period bone distraction was activated at a rate of 0.5mm twice daily for 10 days, followed by a consolidation phase of 8 weeks. During the experiment,8 time--points was chosed to examine, record and analyze the evoked potentials(EP) of IAN : pre-- irradiation, post-- irradiation, pre-- distraction, the sixth day amid distraction, post--distraction, the 2th, 4th, 8th week during consolidation. The neural electricity tester was used to each group to carry out the electrophysiologic analysis. Results: The action potential(AP) of IAN showed corresponding change during the irradiation and distraction process in groupA and B,but groupC did not got integrated AP. Conclusion: Low dose irradiation cannot influence the electrophysiologic change of the IAN during DO while high dose irradiation can severely influence it.

关 键 词:牵张成骨 放射照射 下牙槽神经 动作电位 

分 类 号:R782.2[医药卫生—口腔医学]

 

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