3种烤瓷全冠对龈沟液中TNF-α和IL-1β水平的影响  

Effect of three Kinds of Porcelain Crown on TNF-α and IL-1β Levels in Gingival Crevicular Fluid

作　　者：李宏[1] 沈文静[1] 仇亚非[1] 袁硕[1] 郭长军[1] 

机构地区：[1]河北医科大学口腔医学院,河北省口腔医学重点实验室,河北石家庄050017

出　　处：《口腔医学研究》2015年第3期247-249,253,共4页Journal of Oral Science Research

基　　金：河北省科技支撑计划项目(编号:13277766D);河北省卫生厅医学科学研究重点课题(编号:20090052)

摘　　要：目的:探讨钴铬合金、纯钛金属及二氧化锆不同烤瓷冠基底材料对局部龈沟液中肿瘤坏死因子-α(TNF-α)以及白介素-1β(IL-1β)表达水平的影响。方法:选择临床病例30例,分为3组,分别采用钴铬合金烤瓷冠、纯钛烤瓷冠、二氧化锆全瓷冠修复。在修复前、修复后1个月、3个月分别进行龈沟液(GCF)量、菌斑指数(PLI)、TNF-α和IL-1β表达水平的测定及统计分析。结果:修复前3组之间各检测指标无明显差异;修复后1个月、3个月时钴铬合金烤瓷冠组的GCF量、TNF-α和IL-1β表达水平均高于纯钛烤瓷冠和二氧化锆全瓷冠组;而纯钛烤瓷冠组与二氧化锆全瓷冠组的GCF量、TNF-α和IL-1β水平无显著变化且两组之间各项指标无明显差异。结论:钴铬合金烤瓷冠可导致GCF量及其成分变化,对牙周组织有一定的不利影响,而纯钛烤瓷冠和二氧化锆全瓷冠对牙周组织健康的影响相对较小。Objective： To further investigate the effects of three kinds of materials on the level of tumor necrosis factor--a and interleukin--1β in gingival crevicular fluid （GCF）. Methods： Patients with Co--Cr alloy porcelain crown, titanium porcelain crown and zirconia all--ceramic crown for maxillary anterior teeth of 30 cases were divid- ed into three groups. After for 1 month and 3 months, the amount of gingival crevicular fluid, PLI index, TNF--a and IL--1β levels in gingival crevicular fluid were recorded and analyzed. Results： Before tooth preparation all inde- xes showed no difference among three groups. The level of GCF, TNF-- a and IL-- 1β of Co-- Cr alloy group showed significant difference with Ti PFM and all ceramic crowns after 1 month and 3 months. However, the levels of GCF, TNF--a and IL--1β of Ti PFM group showed no difference with all - ceramic crowns group. Conclusion： The Ti PFM and all--ceramic crown may have less impact on the periodontium than the Co--Cr PFM.

关 键 词：烤瓷全冠 龈沟液 肿瘤坏死因子-Α 白细胞介素-1Β 

分 类 号：R783.2[医药卫生—口腔医学]