成人近视眼眼球生物光学参数测量结果分析  

The analysis of measurement results of adult myopia biological optical parameters

作　　者：王英[1] 邹云春[1] 徐双[1] 杨阳[1] 

机构地区：[1]川北医学院眼视光学系和附属医院眼科,四川省南充637000

出　　处：《中国医师杂志》2015年第3期328-330,336,共4页Journal of Chinese Physician

基　　金：国家自然科学基金资助项目（81341105）和四川省卫生厅课题基金资助项目（120442）

摘　　要：目的：分析18-40岁成年人屈光度与眼球生物光学参数之间的相关性，并评估眼球各生物光学参数对近视发生、发展的影响，为近视防治工作提供科学依据。方法选取18-40岁成年人376只眼，其中正视眼180只，－8．00 D及以内的近视眼196只，用综合验光仪检测屈光度，光学相干生物测量仪（ IOL－master）测量眼轴长度、角膜曲率半径、前房深度，眼科A超测量晶状体厚度及玻璃体深度。结果⑴正视眼组与近视眼组角膜水平曲率半径、角膜垂直曲率半径、眼轴长度、晶状体厚度、前房深度、玻璃体腔深度之间差异有统计学意义（ P ＜0．01）。⑵屈光度数与眼轴长度及玻璃体腔深度呈高度负相关（ r ＝－0．90，－0．88， P ＜0．01）；屈光度与水平角膜曲率半径、垂直曲率半径呈高度正相关（ r ＝0．81，0．84， P ＜0．01）；而屈光度与晶状体厚度、前房深度低度相关（ r ＝－0．11，0．12， P ＜0．01）；眼轴长度和玻璃体腔深度之间呈高度正相关（ r ＝0．95， P ＜0．01）；水平角膜曲率和垂直角膜曲率之间呈高度正相关（ r ＝0．91， P ＜0．01）；眼轴长度与水平角膜曲率和垂直角膜曲率之间呈正相关（ r ＝0．78，0．81， P ＜0．01）。结论屈光状态的两重要影响因素角膜曲率和眼轴长度具有显著正相关关系，寻求促进角膜曲率改变和眼轴增长的共同协同因子及找出控制角膜球形化的反馈机制有利于进一步探索控制近视发生、发展的方法。Objective To investigate the correlations between the ocular biometric optical parame-ters and refractive dioptres in adults, assess the influence of the biometric optical parameters on the develop-ment of myopia, and provide a reference of prevention and treatment for myopia.Methods A total of 188 adults （376 eyes） aged 18 to 40 years old was enrolled in this study.Dioptres were measured with phorop-ter, A-mode ultrasound was used to measure the vitreous length and lens thickness, the axis length, anterior corneal surface semidiameter anterior chamber depth were measured with intraocular len-master （ IOL-mas-ter） .SPSS 17.0 software was used to analyze the date.Results ⑴Of the 376 eyes, the results showed a statistically significant difference between myopia and emetropia in the axis length, vitreous depth, anterior corneal surface semidiameter, anterior chamber depth and lens thickness（ P 〈0.01）.⑵The partial corre-lation analysis indicated a significant positive correlation between the refraction dioptres and axial length, vitreous length （ r =-0.90, -0.88, respectively, P 〈0.01）;and significant strong correlation was also found between dioptres and anterior corneal surface horizontal and vertical semidiameter （ r =0.81, 0.84, respectively, P 〈0.01）;But correlations between dioptres and lens thickness and anterior chamber depth were very weak （ r =-0.11, 0.12, respectively, P 〈0.01）;the correlation between axial length and vit-reous depth was very high （ r =0.95, P 〈0.01）.and the data indicated that the anterior corneal surface horizontal and vertical semidiameter were high positive correlation（ r =0.91, P 〈0.01）;the same high positive correlation between the axial length and the anterior corneal surface semidiameter （ horizontal/verti-cal） was also found （ r =0.78,0.81, P 〈0.01）.Conclusions Two chief factors （corneal surface semi-diameter and ocular axial length） influencing the level of dioptres were high positive correlation, seeking the mutual co

关 键 词：近视/病理生理学 屈光 眼 眼/解剖学和组织学 眼生理学 光学 

分 类 号：R778.11[医药卫生—眼科]