腹腔灌洗治疗肝硬化合并自发性细菌性腹膜炎患者的疗效观察  

Curative effect of peritoneal lavage in treatment of cirrhotic patients with spontaneous bacterial peritonitis

作　　者：杨正茂[1] 施文娟[1] 周渐[1] 王兆勋[1] 

机构地区：[1]兰州市第二人民医院感染科,兰州730046

出　　处：《临床肝胆病杂志》2015年第3期384-386,共3页Journal of Clinical Hepatology

摘　　要：目的探讨腹腔灌洗在肝硬化合并自发性细菌性腹膜炎(SBP)治疗中的价值。方法选取2010年2月-2013年2月兰州第二人民医院感染科收治的肝硬化合并SBP患者86例,随机分为治疗组46例,对照组40例,两组患者均应用静滴抗菌素并放腹水,补充血浆、白蛋白治疗,同时对治疗组患者采用温盐水腹腔灌洗和腹腔内注射抗菌素治疗,比较两组疗效。计数资料采用百分比表示,组间比较采用χ2检验。结果治疗组的治疗有效率为76.09%,优于对照组47.50%(χ2=7.4836,P<0.05);治疗组病死率为17.39%,低于对照组37.50%(χ2=4.4159,P<0.05),两组在有效率和病死率上差异均有统计学意义。结论腹腔灌洗是治疗肝硬化合并SBP的有效方法。Objective To investigate the value of peritoneal lavage in the treatment of cirrhotic patients with spontaneous bacterial peritonitis（ SBP）. Methods Eighty-six cirrhotic patients with SBP who were admitted to the Department of Infection in our hospital from February 2010 to February 2013 were selected and randomly divided into treatment group（ n = 46） and control group（ n = 40）. The two groups were both treated with intravenous antibiotic therapy,therapeutic paracentesis,and intravenous plasma and albumin. Meanwhile,the treatment group received peritoneal lavage with warm saline,and intraperitoneal antibiotic administration. The curative effects were compared between the two groups. Categorical data were expressed as percentage and compared between the two groups by chi- square test. Results The response rate in the treatment group was significantly higher than that in the control group（ 79. 09% vs 14. 50%,χ2= 7. 4836,P 〈0. 05）. The case- fatality rate in the treatment group was significantly lower than that in the control group（ 17. 39% vs 37. 50 %,χ2=4. 4159,P 〈 0. 05）. Conclusion Peritoneal lavage is an effective method in the treatment of cirrhotic patients with SBP.

关 键 词：肝硬化 腹膜炎 腹腔灌洗 

分 类 号：R575.2[医药卫生—消化系统]