肝硬化患者支链氨基酸的应用进展  

Progress in application of branched- chain amino acids in patients with liver cirrhosis

作　　者：吕铮[1] 孟庆华[1] 

机构地区：[1]首都医科大学附属北京佑安医院肝病重症医学科,北京100069

出　　处：《临床肝胆病杂志》2015年第3期475-477,共3页Journal of Clinical Hepatology

基　　金：国家卫计委2014重点建设专科项目(WJWYA-2014-001);北京市科技计划重大项目(H020920020890)

摘　　要：氨基酸主要在肝脏代谢,肝硬化患者的蛋白质、糖类、脂肪代谢紊乱,体内氨基酸代谢失衡,继而引起全身多脏器、多系统的功能不全,出现肝性脑病、食管静脉曲张破裂出血、腹水等并发症,导致较高的病死率。总结了肝硬化患者氨基酸代谢特点及支链氨基酸在肝硬化治疗中的应用,指出支链氨基酸制剂在调整肝病患者的血清氨基酸谱,升高支链氨基酸与芳香族氨基酸的比值,预防肝硬化并发症,提高肝硬化患者生活质量方面具有重要作用。The metabolism of amino acids mainly takes place in the liver,and patients with liver cirrhosis may develop metabolic disorders of proteins,carbohydrates,fats,and amino acids,which in turn causes dysfunction of multiple organs and systems,as well as complications like hepatic encephalopathy,esophageal variceal bleeding,and ascites,resulting in high mortality. This paper summarizes the metabolic characteristics of amino acids and the application of branched- chain amino acids（ BCAAs） in the treatment of liver cirrhosis,and it points out the significance of BCAAs in regulating serum aminogram,increasing the ratio of BCAAs to aromatic amino acids,preventing complications of liver cirrhosis,and improving the quality of life for patients with the disease.

关 键 词：肝硬化 氨基酸类 支链 肝性脑病 低蛋白血症 胰岛素抗药性 综述 

分 类 号：R575.2[医药卫生—消化系统]