血管生物学在门静脉高压症治疗中的作用  

Role of vascular biology in portal hypertension

作　　者：任晓丽[1] 时永全[1] 韩英[1] 

机构地区：[1]第四军医大学西京消化病医院肿瘤生物学国家重点实验室,西安710032

出　　处：《临床肝胆病杂志》2015年第3期478-480,I0001,共4页Journal of Clinical Hepatology

摘　　要：门静脉高压症的发生与肝内外血管的显著改变有关,随着对血管生物学的深入研究,目前对与门静脉高压症有关的动态血管变化的机制有了更加深入的了解。综述了与门静脉高压症相关的血管生物学进展,如肝血管细胞以及它们的信号通路发生变化与肝内血管阻力增加有关,从而导致了门静脉高压症的发生,而肠系膜动脉血管舒张致使进入门静脉的血流量增加,加剧了门静脉高压。进一步深入了解它们的作用机制及靶向分子通路,将为治疗门静脉高压提供新的前景。The development of portal hypertension is associated with remarkable changes in the intra- and extra- hepatic vasculature. Thus far,in-depth research into vascular biology has furthered our understanding about the mechanism of dynamic vascular changes associated with portal hypertension. Advances in portal hypertension- related vascular biology are reviewed. Alterations in hepatic vascular cells and their signaling pathways are associated with increases in the intra- hepatic resistance,eventually resulting in the development of portal hypertension. Due to mesenteric arterial vasodilation,increased blood flow enters the portal vein and exacerbates portal hypertension. Better understanding of relevant mechanisms and targeted molecular pathways will provide new prospects for the treatment of portal hypertension.

关 键 词：高血压 门静脉 肝星状细胞 血管重建 综述 

分 类 号：R575.2[医药卫生—消化系统]