综合认知训练对轻度认知功能损害的干预效果  

Effect of integrative cognitive training on mild cognitive impairments： a one-year follow-up study

作　　者：冯威[1] 李春波[2] 陈优[3] 成燕[1] 吴文源[1] 

机构地区：[1]上海同济大学附属同济医院精神医学科,200065 [2] 上海交通大学医学院附属精神卫生中心 [3] 上海市杨浦区精神卫生中心

出　　处：《中华老年医学杂志》2015年第4期355-358,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金资助项目（81200831、30770769）;上海市卫生局课题（2012038）

摘　　要：目的 探索综合认知训练对轻度认知功能损害（MCI）的中短期干预效果.方法 对上海市某街道社区70岁以上MCI老年人（干预组46例,对照组35例）进行12周（共24次）的综合认知训练.分别于基线、干预结束、干预后1年采用中国老年成套神经心理测验（NTBE）及自制健康问卷对两组进行测评.结果 （1）基线：干预组NTBE中语义联系项优于对照组（t=2.13,P=0.037）,词汇流畅蔬菜测验项低于对照组（t=-2.25,P=0.038）,其他测验两组差异均无统计学意义（均P＞0.05）.（2）1年随访组内比较：干预组NTBE推理测验（t=-2.70,P=0.010）等16项提高,2项下降（均P＜0.05）.对照组NTBE语义联系（t=-2.27,P=0.013）等9项提高,5项下降（均P＜0.05）.（3）1年随访组间比较：干预组NTBE推理测验（F=16.80,P=0.000）等5项优于对照组（均P＜0.05）.（4）3次随访重复测量方差分析NTBE推理测验（F=5.16,P=0.01）等4项分测验存在时间与组别交互作用（均P＜0.05）.结论 综合认知训练对MCI部分认知领域有改善作用,其中推理能力有效性可持续一年.Objective To evaluate the middle and short-term effects of integrative cognitive training on mild cognitive impairments（MCI）.Methods All the participants with MCI aged over 70 years were selected from one sub-district of Putuo District,Shanghai and divided into cognitive intervention group （n=46） and control group （n=35）.The integrative cognitive training was conducted in 24 sessions for 12 weeks.All subjects were assessed by Neuropsychological Test Battery for Elderly （NTBE） and by a questionnaire of ＆quot;Shanghai Health Survey for the Elderly （VER2006）＆quot;at baseline,follow-up and one-year follow up phases.Results At baseline phase,semantic relations test in NTBE was better （t=2.13,P=0.037）,verbal fluency test （vegetables） in NTBE was worse（t =-2.25,P=0.038） in intervention group than in control group,while there were no significant differences in scores of other neuropsychological tests between intervention group and control group（all P〉0.05）.At follow up phase,16 subscales in reasoning test of NTBE were improved （t=-2.70,P=0.010）and 2 subscales were declined in cognitive intervention group（all P〈0.05）.9 subscales in semantic relations test of NTBE （t=-2.27,P=0.013） were improved and 5 subscales were declined in control group （all P〈 0.05）.Comparison between groups at one year follow-up showed that 5 subscales in reasoning test of NTBE （F=16.80,P=0.000） were better in intervention group than in control group（all P〈0.05）.General linear model （GLM） with repeated measures at three time points showed that 4 subscales in reasoning test of NTBE had a time-by group interaction （F=5.16,P=0.01）.Conclusions Integrative cognitive training can improve cognitive function in patients with mild cognitive impairments,and the validity of reasoning ability can sustain one year.

关 键 词：认知障碍 干预性研究 认知疗法 

分 类 号：R749.1[医药卫生—神经病学与精神病学]