Bmi-1和hTERT在结直癌组织中的表达和相关性  

EXPRESSIONS AND CORRELATIONS OF BMI-1 AND HTERT IN COLORECTAL CARCINOMA

作　　者：胡占锋[1] 李淑全 严鹏[1] 徐瑞云[1] 郑纪宁[1] 

机构地区：[1]承德医学院,河北承德067000 [2]承德市第三医院

出　　处：《承德医学院学报》2015年第2期93-95,共3页Journal of Chengde Medical University

摘　　要：目的:探讨Bmi-1和h TERT在结直肠癌发生发展中的作用。方法:采用免疫组织化学染色法检测Bmi-1蛋白和h TERT表达水平。结果:结直肠癌组织Bmi-1和h TERT的阳性表达率明显高于癌旁正常黏膜(P<0.05)。Bmi-1、h TERT阳性表达与病理分期、浸润深度和有无淋巴结转移有关(P<0.05),与性别和分化程度无关(P>0.05)。结直肠癌组织Bmi-1和h TERT的表达呈正相关关系(P<0.05)。结论:Bmi-1和h TERT与结直肠癌的发生发展密切相关,且二者在结直肠癌发生发展中具有协同作用。Objective： To investigate the actions of Bmi-1 and h TERT in development of colorectal carcinoma.Methods： Immunohistochemical stain was used to detect the expression of Bmi-1 and h TERT. Results：The positive expression rate of Bmi-1 and h TERT in colorectal carcinoma were obviously higher than that in para-carcinoma normal mucosa（P〈0.05）. The positive expression of Bmi-1 and h TERT in colorectal carcinoma were associated with pathological stage, infi ltration depth and lymph node metastasis（P〈0.05）; but not associated with age and differentiated degree（P〈0.05）. In colorectal carcinoma, the expression of Bmi-1 was positively related to h TERT（P〈0.05）.Conclusions：Bmi-1 and h TERT are closely related to development of colorectal carcinoma; Moreover, they also have synergistic effects in development of colorectal carcinoma.

关 键 词：结直肠癌 BMI-1 HTERT 免疫组织化学染色 

分 类 号：R735.3[医药卫生—肿瘤]