首发精神分裂症治疗前后血清NGF、BDNF、GFAP与临床症状的相关性研究  

Correlation between pre-and post-treatment serum levels of NGF,BDNF,GFAP and severity of clinical symptoms in patients with first-episode schizophrenia

作　　者：牛莉莉[1] 温科奇 熊鹏[1] 曾勇[1] 徐飞[1] 李明[1] 黄晓江[1] 

机构地区：[1]昆明医科大学第一附属医院,云南昆明650031

出　　处：《精神医学杂志》2015年第1期10-12,共3页Journal of Psychiatry

基　　金：国家自然科学基金项目(编号:81360210);云南省社会发展科技计划项目(编号:2011CA018);云南省应用基础研究计划项目(编号:2011FB172)

摘　　要：目的分析神经生长因子(NGF)、脑源性神经营养因子(BDNF)、血清胶质纤维酸性蛋白(GFAP)血清浓度在精神分裂症患者治疗前后的变化及与临床症状的相关性。方法用ELISA方法检测50例首发精神分裂症患者(研究组)和78例正常对照者(对照组)血清NGF、BDNF、GFAP水平,研究组用利培酮治疗3个月后再次检测血清NGF、BDNF、GFAP水平。研究组治疗前后用阳性和阴性综合征量表(PANSS)评定临床症状变化。结果研究组治疗前GFAP血清浓度高于对照组(P<0.01),NGF、BDNF血清浓度低于对照组(P<0.01);研究组治疗后3种蛋白因子血清浓度均低于治疗前(P<0.05)。研究组治疗后PANSS总分、阳性症状分、阴性症状分及一般精神病理评分均低于治疗前(P<0.01)。研究组治疗前NGF、GFAP血清浓度和PANSS阴性症状评分呈正相关(P<0.05);研究组治疗后NGF血清浓度和PANSS阴性症状评分呈负相关(P=0.000),BDNF和PANSS一般病理评分呈正相关(P=0.002),GFAP血清浓度和PANSS一般病理评分呈负相关(P=0.024)。结论首发精神分裂症患者NGF、BDNF与GFAP血清浓度随精神症状的改善而变化,NGF、BDNF与GFAP与精神分裂症的发病及转归过程可能具有一定相关性。Objective To explore the changes of serum levels of Nerve Growth Factor （NGF）,Brain-Derived Neurotrophic Factor （BDNF）,Glial Fibrillary Acidic Protein （GFAP）in patients with first-episode schizophrenia,and to explore the correlation with severity of clinical symptoms pre-and post-treatment.Methods Serum levels of NGF,BDNF and GFAP were measured by using ELISA in 50 patients with first-episode schizophrenia （study group）and 78 healthy controls （control group）, and were re-measured in subjects in study group after 3-month risperidone treatment.All patients in study group were assessed with Positive and Negative Syndrome Scale（PANSS）at baseline and at the end of the 3-month treatment to evaluate the severity of clinical symptoms.Results The pre-treatment serum level of GFAP in study group was significantly higher than that in control group （P 〈0.01）,pre-treatment serum levels of NGF and BDNF in study group were significantly lower than those in control group （P 〈0.01）.Serum levels of the 3 protein factors at the end of the treatment in study group were significantly lower than those at the baseline （P 〈0.05）.Total score of PANSS and factor scores of positive symptoms,negative symptoms and general psychopathology at endpoint in study group were significantly lower than those at baseline （P 〈0.01）.In study group,the pre-treatment serum level of NGF and GFAP were significantly positively correlated with factor score of negative symptoms of PNASS （P 〈0.05 ）.The post-treatment NGF level was significantly negatively correlated with factor score of negative symptoms of PNASS （P =0.000 ）.Post -treatment BDNF level was significantly positively correlated with factor score of general psychopathology （P =0.002）,while post-treatment GFAP level was significantly negatively correlated with it （P =0.024）. Conclusion Serum levels of NGF,BDNF and GFAP change with the improvement of clinical symptoms in patients with first-episode schizophrenia.NGF,BDNF and GFAP may be

关 键 词：精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]