miR-128在急性淋巴细胞白血病中的表达  

Expression of miR-128 in patients with acute lymphoblastic leukemia

作　　者：符爽 胡延平[1] 张男[1] 陈芳[1] 刘璇[1] 张旻昱[1] 姜若腾 张继红[1] 

机构地区：[1]中国医科大学附属盛京医院血液研究室,沈阳110022

出　　处：《白血病．淋巴瘤》2015年第3期178-180,183,共4页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金青年基金（81300420）

摘　　要：目的 探讨miR-128在急性淋巴细胞白血病（ALL）中的表达及其意义.方法 采用实时荧光定量聚合酶链反应法对62例ALL患者和20例骨髓正常患者骨髓单个核细胞miR-128的相对表达量进行检测,并与患者的临床资料进行相关性分析.结果 miR-128在ALL患者中的相对表达量高于健康对照组（P＜0.05）,但其在急性B淋巴细胞白血病（B-ALL）及急性T淋巴细胞白血病（T-ALL）中的表达水平差异无统计学意义（P＞0.05）,miR-128的表达与是否存在bcr-abl融合基因及其mRNA的表达水平均无相关性（均P＞ 0.05）.结论 miR-128在ALL患者中表达上调,可作为临床诊断ALL的潜在分子标志物,bcr-abl融合基因的表达对miR-128在ALL中的表达无明显影响.Objective To investigate the expression and clinical significance of miR-128 in acute lymphoblastic leukemia （ALL）.Methods The relative expression levels of miR-128 from bone marrow cells were detected by real time PCR in 62 patients with ALL and 20 normal subjects,and the correlations between miR-128 expression and its clinical characteristics were analyzed.Results The relative expression level of miR-128 in ALL was higher than that in normal subjects （P 〈 0.05）,but there was no statistical difference in miR-128 expression levels between B-ALL and T-ALL patients （P 〉 0.05）,and no significant correlation was found between miR-128 expression level and bcr-abl positive rates or bcr-abl mRNA level in ALL （P 〉 0.05）.Conclusion miR-128 is up-regulated in ALL patients,which may provide a novel ALL diagnostic marker.There was no obvious influence of bcr-abl fusion gene on miR-128 expression in ALL patients.

关 键 词：急性淋巴细胞白血病 

分 类 号：R733.71[医药卫生—肿瘤]