HIF-1α和LOX在非小细胞癌中的表达及其临床意义  

Expression and significance of hypoxia inducible factor-1α and lysyl oxidase in non-small cell lung cancer

作　　者：平伟[1] 高轶[1] 邓豫[1] 孙威[1] 付向宁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院胸外科

出　　处：《临床外科杂志》2015年第3期218-220,共3页Journal of Clinical Surgery

摘　　要：目的：检测缺氧诱导因子-1α（ Hypoxia inducible factor-1α，HIF-1α）及赖氨酰氧化酶（Lysyl oxidase，LOX）在非小细胞肺癌（ non-small cell lung cancer，NSCLC）中的表达，探讨二者在NSCLC发生、发展及转移中的作用。方法采用免疫组织化学方法，分别检测HIF-1α和LOX在不同临床病理特征中的变化。结果 HIF-1α和LOX在NSCLC肿瘤组织中表达均明显高于癌旁组织，二者均与肿瘤大小、淋巴结转移和肿瘤分期有关，差异有统计学意义（ p〈0.05），两者间呈正相关（p〈0.05）。结论 HIF-1α和LOX在NSCLC的发生、发展中发挥重要的调节作用，可共同促进NSCLC的进展。Objective Objective To detect the expression of hypoxia inducible factor-1α（ HIF-1α）and lysyl oxidase（ LOX）in non-small cell lung cancer（ NSCLC）and investigate their significance in pathogenesis,development and metastasis in NSCLC. Methods The expression of HIF-1α and LOX was detected in tissues with various pathological characters by immunohistochemistry method. Results The expression of HIF-1α and LOX in NSCLC tumor tissues was significantly higher than those in paired nor-mal tissues. There was significant correlation between the expression of HIF-1α or LOX and tumor size, lymph node metastasis and pathological stage（p〈0. 05）. The expression of HIF-1α protein was signifi-cantly correlated with LOX in NSCLC（p〈0. 05）. Conclusion HIF-1αand LOX may play a pivotal role in the development of NSCLC,and may act in synergy to promote the progression of NSCLC.

关 键 词：HIF-1Α LOX NSCLC 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]