胃癌转移相关长链非编码RNA的研究进展  

Research Progress of Gastric Cancer Related lncRNAs

作　　者：杨自国 郭晓波[1] 石玉龙[1] 李乐平[1] 

机构地区：[1]山东大学附属省立医院胃肠外科,山东济南250021

出　　处：《中国普外基础与临床杂志》2015年第4期513-516,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结目前长链非编码RNA(long noncoding RNA,lnc RNA)在胃癌转移中的作用及研究进展。方法通过Web of Knowledge、Pubmed等数据库检索并下载有关lnc RNAs和胃癌转移相关文献,对lnc RNAs参与胃癌转移相关文献进行分析。结果近年来lnc RNAs作为研究热点,越来越受到研究者的重视,它们能够在染色质、转录和转录后水平参与基因调节。lnc RNAs在胃癌中异常表达,并通过调节胃癌血管生成、细胞间连接和细胞外基质调节胃癌转移。结论 lnc RNAs作为胃癌转移的重要调节因素,可以作为胃癌治疗的分子靶点,为深入研究如何防治胃癌的转移提供了一种有效的科学思路。Objective To summarize the research progress of long noncoding RNA（lnc RNA） in the metastasis of gastric cancer. Methods The related works of lnc RNAs in gastric cancer metastasis were searched from databases like Web of Knowledge and Pubmed, and analyzed after collected. Results The emerging of lnc RNAs has led to mounting interest in recent years. Increasing studies have elucidated that lnc RNAs can regulate gene expression at the level of chromatin, transcription or posttranscription. Some aberrantly expressed lnc RNAs have been revealed to modulate gastric cancer metastasis by regulating angiogenesis, cell to cell junction, and extracellar matrix. Conclusion As essential regulators, lnc RNAs can act as therapeutic targets, providing therapeutic bases to prevent gastric cancer metastasis.

关 键 词：长链非编码RNA 胃癌 转移 进展 

分 类 号：R735.2[医药卫生—肿瘤]