海洛因诱导位置偏爱大鼠额叶联络皮层脑电样本熵分析  

Analysis of Electroencephalogram Sample Entropy Measurement in Frontal Association Cortex Based on Heroin-induced Conditioned Place Preference in Rats

作　　者：黄磊[1] 潘群皖[2] 朱再满[2] 李晶[2] 高春芳[1] 李田[1] 徐晓燕[1] 

机构地区：[1]皖南医学院医学工程学教研室,芜湖241002 [2]皖南医学院生理教研室,芜湖241002

出　　处：《生物医学工程学杂志》2015年第2期275-278,283,共5页Journal of Biomedical Engineering

基　　金：安徽省高校省级科学研究一般项目资助(KJ2013B321);安徽省自然科学基金资助项目(090413096)

摘　　要：为了探究海洛因诱导位置偏爱大鼠的觅药行为及动机形成与样本熵值之间的关联,在黑、白箱停留、白-黑箱穿梭、黑-白箱穿梭四种不同的大鼠行为状态下,研究对照组与海洛因诱导条件性位置偏爱(CPP)组大鼠的前额联络皮层(FrA)脑电(EEG)数据样本熵值。实验结果表明,与对照组比较,海洛因诱导CPP大鼠在白-黑箱穿梭和黑箱停留状态时,FrA区EEG样本熵值无显著改变;但黑-白箱穿梭和白箱停留状态时,FrA区EEG样本熵值显著变小(P<0.01)。由此可见,海洛因诱导CPP大鼠觅药动机形成及其行为与EEG样本熵值改变之间密切相关。To explore the relationship between the drug-seeking behavior,motivation of conditioned place preference（CPP）rats and the frontal association cortex（FrA）electroencephalogram（EEG）sample entropy,we in this paper present our studies on the FrA EEG sample entropy of control group rats and CPP group rats,respectively.We invested different behavior in four situations of the rat activities,i.e.rats were staying in black chamber of videoed boxes,those staying in white chamber of videoed boxes,those shuttling between black-white chambers and those shuttling between white-black chambers.The experimental results showed that,compared with the control group rats,the FrA EEG sample entropy of CPP rats staying in black chamber of video box and shuttling between whiteblack chambers had no significant difference.However,sample entropy is significantly smaller（P0.01）when heroin-induced group rats stayed in white chamber of video box and shuttled between black-white chambers.Consequently,the drug-seeking behavior and motivation of CPP rats correlated closely with the EEG sample entropy changes.

关 键 词：海洛因 条件性位置偏爱 额叶联络皮层 样本熵 

分 类 号：R749.64[医药卫生—神经病学与精神病学]