2型糖尿病患者轻度认知障碍多通道同步性分析  

Multi-channel Synchronization Analysis of Mild Cognitive Impairment in Type 2 Diabetes Patients

作　　者：崔冬[1] 刘静[1] 边志杰[2] 王金焕[1] 李秋俐[3] 李小俚[2] 王磊[3] 

机构地区：[1]燕山大学信息科学与工程学院,秦皇岛066004 [2]燕山大学电气工程学院,秦皇岛066004 [3]第二炮兵总医院神经内科,北京100088

出　　处：《生物医学工程学杂志》2015年第2期279-283,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(61102005;61271142);国家杰出青年基金资助项目(61025019);河北省自然科学基金资助项目(F2014203132)

摘　　要：2型糖尿病患者因长期代谢紊乱造成的认知功能障碍已经成为当前关注的重点。本文利用多通道同步方法——基于相位同步的S估计器对脑电信号进行同步分析,以期发现与糖尿病轻度认知障碍有关的脑电特性。结果显示:糖尿病轻度认知障碍患者与正常对照组相比各脑区各频段的S值均减小,尤其是δ和α频段显著降低,表明脑电同步值降低;患者MoCA得分与S值在α频段具有显著的正相关性。The cognitive impairment of type 2diabetes patients caused by long-term metabolic disorders has been the current focus of attention.In order to find the related electroencephalogram（EEG）characteristics to the mild cognitive impairment（MCI）of diabetes patients,this study analyses the EEG synchronization with the method of multichannel synchronization analysis--S estimator based on phase synchronization.The results showed that the S estimator values in each frequency band of diabetes patients with MCI were almost lower than that of control group.Especially,the S estimator values decreased significantly in the delta and alpha band,which indicated the EEG synchronization decrease.The MoCA scores and S value had a significant positive correlation in alpha band.

关 键 词：2型糖尿病 轻度认知障碍 多通道同步 相位同步 S估计器 

分 类 号：R587.1[医药卫生—内分泌] R749.24[医药卫生—内科学]