替吉奥联合放疗治疗老年局部晚期食管癌疗效观察  

Evaluation of Chemoradiotherapy with S-1 for Elder Patients with Local Advanced Esophageal Cancer

作　　者：龙翔宇[1] 周伟[1] 王兴远[1] 李仕娟[2] 张剑青[3] 

机构地区：[1]广安市人民医院,四川广安638001 [2]云南省肿瘤医院,云南昆明650118 [3]昆明医科大学第一附属医院,云南昆明650032

出　　处：《昆明医科大学学报》2015年第4期121-124,共4页Journal of Kunming Medical University

基　　金：四川省卫生厅科研基金资助项目(080133)

摘　　要：目的 探讨替吉奥联合放疗治疗老年局部晚期食管癌的有效性及安全性.方法66例老年局部晚期食管癌患者,随机分为对照组32例：采用三维适形放疗DT=54 Gy/30f.治疗组34例：替吉奥,60～80mg/（m2.d）,2次/d,连服14d,停药7d,21d为1个周期,共2周期,同步放疗54 Gy/30 f.结果对照组、治疗组有效率分别为59.4%,82.4%（χ^2=4.246,P=0.039）;中位疾病进展时间分别为4.0月（95%CI：2.91～5.10）和6.0月（95%CI：4.58～7.42;P=0.04）,差异有统计学意义.中位生存时间8.0月（95%CI：6.01～10.00）和11.0月（95%CI：9.45～12.52;P=0.039）,差异有统计学意义,治疗组血液学毒性高于对照组,但易于处理.结论替吉奥联合放疗治疗老年局部晚期食管癌安全有效.Objective To evaluate the efficacy and adverse reactions of chemoradiotherapy with S-1 for elder patients with local advanced esophageal cancer. Methods Total of 66 elder patients with local advanced esophageal cancer were randomized into two groups. 32 cases as control group, received 3D conformal radiation therapy with DT： 54Gy/30f only. 34 cases as therapy group, S-1 was administered two cycles, 60-80 mg/（m2.d） on days 1-14, every 21 days as a cycle, combined with 3D conformal radiation therapy with same dose. Results The response rate of control group and therapy group was 59.4% and 82.4% （ X 2 = 4.246, P = 0.039） , respectively. The median time to progression was months 4.0 （95%CI： 2.91-5.10） and 6.0 months （95%CI： 4.58-7.42; P = 0.04） . The median survival time was 8.0 months （95%CI： 6.01-10.00） and 11.0 months （95%CI： 9.45-12.52; P = 0.039） . There were significant differences between the two groups. The incidence rate of myelosuppression was higher in therapy group, but was easy to handle. Conclusion S-1 combined with 3D conformal radiation therapy showed reliable efficacy and the toxicity was tolerable.

关 键 词：食管癌 三维适形治疗 替吉奥 化疗 

分 类 号：R735.1[医药卫生—肿瘤]