磷酸酯酶与张力蛋白同源物和白血病干细胞关系的研究进展  

Research progress of relationship between phosphatase and tensin homolog and leukemic stem cell

作　　者：张焕新[1] 徐开林[1] 

机构地区：[1]徐州医学院附属医院血液科,221002

出　　处：《国际输血及血液学杂志》2015年第2期119-122,共4页International Journal of Blood Transfusion and Hematology

基　　金：国家自然科学基金资助项目（81300399）

摘　　要：白血病干细胞与白血病的发生、耐药及复发有关,要根除白血病,应考虑以白血病干细胞为治疗靶点.然而,白血病干细胞与正常造血干细胞具有很多相似特点,如何根除白血病干细胞而不影响正常造血干细胞的功能给研究者们提出了巨大挑战.近年研究发现,磷酸酯酶与张力蛋白同源物（PTEN）对造血干细胞与白血病干细胞的影响机制不同,这为白血病的靶向治疗带来机会.笔者拟就近年来有关PTEN对白血病干细胞及造血干细胞的影响机制及调节机制研究进行综述,旨在为白血病的靶向治疗提供新思路.Leukemia stem cells are considered responsible for the occurrence,prognosis,relapse and resistance to chemotherapy of leukemia.In order to completely eradicate leukemia cells and consequently cure the disease,leukemia stem cells therapies should be considered as a therapeutic target.However,the fact that leukemia stem cells share functional and phenotypic properties with normal hematopoietic stem cells poses a significant challenge to researchers：how to definitely eradicate leukemia stem cells without damaging normal hematopoietic stem cells and compromising hematopoiesis.In recent years,researchers found that phosphatase and tensin homolog （PTEN） regulates leukemia stem cells and hematopoietic stem cells through different mechanisms.And this discovery demonstrates that it is possible to identify pathways that differentially impact leukemia and normal stem cell function and opens new therapeutic perspectives for the selective elimination of leukemia stem cells.In this review,we briefly discuss the mechanisms that regulate PTEN function in leukemia stem cells and hematopoietic stem cells and their potential for the development of leukemia stem cells-targeted therapies.

关 键 词：白血病 磷酸酯酶与张力蛋白同源物 白血病干细胞 1-磷脂酰肌醇3-激酶/Akt/哺乳动物雷帕霉素靶蛋白信号通路 

分 类 号：R733.7[医药卫生—肿瘤]