复方丹参滴丸联合雷贝拉唑治疗老年慢性萎缩性胃炎的疗效及对患者血清胃泌素和内皮素的影响  

Compound salvia pellet in combination with rebeprazole for treatment of elderly patients with chronic atrophic gastritis: Curative efficacy and effect on serum gastrin and endothelin

作　　者：李蓉[1] 杨发满[1] 刘冀[1] 杨青岩[1] 汪元浚[1] 李军[1] 张培莉[1] 王卓亚[1] 李晓平[1] 敬泽慧[1] 

机构地区：[1]青海大学附属医院老年二科,青海省西宁市810001

出　　处：《世界华人消化杂志》2015年第8期1298-1302,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨复方丹参滴丸联合雷贝拉唑治疗老年慢性萎缩性胃炎疗效及对患者血清胃泌素和内皮素的影响.方法:160例符合纳入标准的慢性萎缩性胃炎患者随机分为2组,每组各80例.随意患者给予阿莫西林+克拉霉素治疗,在此基础上对照组给予雷贝拉唑治疗,观察组在对照组的基础上联合应用复方丹参滴丸治疗.疗程结束后,观察比较两组患者临床疗效、症状改善情况、胃黏膜病理检查变化情况、血清胃泌素-17、内皮素-1(endothelin-1,ET-1)水平.结果:观察组总有效率为93.8%,明显高于对照组81.2%的总有效率(P<0.05).治疗后,与对照组相比,观察组存在上腹胀痛、嗳气、反酸和恶心症状的患者例数明显减少,胃黏膜萎缩、肠上皮化生、不典型增生例数均显著减少,血清胃泌素-17水平明显升高,ET-1水平明显下降,比较都有统计学差异(均P<0.05).治疗过程中,均未出现严重不良反应.结论:复方丹参滴丸联合雷贝拉唑治疗慢性萎缩性胃炎疗效可靠,可以提高治疗有效率高,显著改善临床症状、胃黏膜病变,促进分泌胃泌素,降低血清内皮素水平,且不良反应少,临床上值得进一步研究.AIM： To assess the clinical effects of compound salvia pellet in combination with rebeprazolein the treatment of elderly patients with chronic atrophic gastritis（CAG） and the effect on serum gastrin and endothelin. METHODS： One hundred and sixty CAG patients were randomly and equally divided into two groups： a control group and an observation group. Besides amoxicillin and clarithromycin, the control group was treated with rebeprazole, while the observation group was treated with compound salvia pellet and rebeprazole. The curative efficacy, improvement of clinical symptoms, pathological changes of the gastric mucosa and levels of serum gastrin-17 and endothelin-1（ET-1） were observed and compared for the two groups. RESULTS： The observation group had a response rate of 93.8%, which was significantly higher than that in the control group（81.2%; P〈0.05）. After treatment, the observation group had significantly fewer cases with upper abdominal distention and pain, eructation, acid regurgitation and nausea than those in the control group（P〈0.05 for all）. As to pathological results of the gastric mucosa, the observation group had significantly fewer cases with gastric mucosal atrophy, intestinal metaplasia and atypical hyperplasia than those in the control group（P〈0.05）. In comparison with the control group, serum level of gastrin-17 was statistically higher and that of ET-1 was statistically lower in the treatment group（P〈0.05 for both）. During the treatment, there were no severe adverse reactions. CONCLUSION： Combined compound salviapellet with rebeprazole in elderly patients with CAG is effective, and can increase the response rate, significantly improve clinical symptoms and gastric mucosal lesions, promote secretion of gastrin and decrease endothelin level with fewer adverse reactions.

关 键 词：复方丹参滴丸 雷贝拉唑 慢性萎缩性胃炎 胃泌素-17 内皮素-1 

分 类 号：R573.32[医药卫生—消化系统]