BDNF rs6265和COMT rs4680与广西壮族散发性帕金森病的相关性研究  

Association study between rs6265 and rs4680 on sporadic Parkinson's disease in Zhuang population

作　　者：梁庆华[1] 庞国防[1] 吕泽平[1] 胡才友[1] 黄东挺[1] 周博峰[1] 黄春丽[1] 余天智[1] 唐凤川[1] 葛琳[2] 潘尚领[2] 彭均华[2] 

机构地区：[1]广西壮族自治区江滨医院,南宁530021 [2]广西医科大学病理生理学教研室

出　　处：《陕西医学杂志》2015年第4期419-420,共2页Shaanxi Medical Journal

基　　金：国家自然科学基金项目(31160209);广西自然科学基金项目(2011GXNSFA018278)

摘　　要：目的:探讨脑源性神经营养因子(BDNF)rs6265和儿茶酚胺氧位甲基转移酶(COMT)rs4680的多态性与广西壮族散发性帕金森病(PD)的相关性。方法:使用PCR-RFLP法对112例壮族散发性PD患者的rs6265和rs4680位点进行基因分型,并与156例健康壮族老年人比较,分析这两个多态与PD的相关性。结果:除PD早发亚组rs6265基因型GG的频率高于同年龄段对照组(P<0.05),两组间的等位基因及基因型频率均无统计学差异(P>0.05)。两位点A等位基因罹患PD的风险与正常人群无异,OR分别为1.212(P=0.572)和0.985(P=0.427)。结论:rs6265和rs4680与广西壮族散发性PD的遗传易感缺乏关联性。Objectives：To investigate the correlation between BDNF rs6265 and COMT rs4680 on sporadic Parkinson＇s disease（PD）in Zhuangs.Methods：PCR-RFLP was employed to genotype rs6265 and rs4680for112sporadic PD patients and 156 controls.Results：No difference on allelic and genotypic frequencies was found between the two groups（all P〉0.05）under any genetic models except that the GG genotype of rs6265 was higher in the early-onset PD subgroup as compared to controls（P〈0.05）.Similar PD risk for A and non-A allele carriers was found on both SNP（rs6265：OR = 1.212,P = 0.572;rs4680：OR = 0.985,P = 0.427）.Conclusions：No association between rs6265 and rs4680and the susceptibility of sporadic PD in Zhuangs.

关 键 词：帕金森病 脑源性神经营养因子 @儿茶酚胺氧位甲基转移酶 

分 类 号：R742.5[医药卫生—神经病学与精神病学]