声动力学疗法治疗脑动脉粥样硬化机制的研究进展  

Progression of sonodynamic treatment on cerebral atherosclerosis

作　　者：高鑫[1] 丛大民 陈磊[1] 沈大伟[1] 张旭凤[1] 高万龙[1] 胡韶山[1] 

机构地区：[1]哈尔滨医科大学附属二院神经外科,哈尔滨市150086

出　　处：《临床超声医学杂志》2015年第3期188-190,共3页Journal of Clinical Ultrasound in Medicine

基　　金：教育部新世纪优秀人才支持计划(NCET-09-0131)

摘　　要：声动力学疗法是利用超声的物理能量激活声敏剂发生化学反应,产生活性氧,从而发挥生物学效应。动脉粥样硬化(AS)是一种免疫炎症性疾病,巨噬细胞作为主要的免疫细胞,在AS斑块形成、发展、不稳定及斑块破裂过程中均发挥关键作用。声动力学疗法可通过抑制动脉粥样硬化中的炎症和免疫反应,从而达到治疗的目的。该疗法简单、费用低,创伤小、安全性高,在脑AS的应用前景广阔。本文就声动力学疗法治疗脑AS机制的研究进展做一综述。Sonodynamic therapy is using of ultrasonic sound physical energy to activate the sound sensitizer chemical reaction,generation of reactive oxygen to exert biological effects.Atherosclerosis（AS） is an inflammatory disease of the immune, macrophages as the primary immune cells plays key role in AS plaque formation,development,instability and plaque rupture processes. Sonodynamic therapy by inhibiting AS in inflammatory and immune responses,so as to achieve the purpose of treatment. The therapy has broad application in AS with relatively simple,low cost,less invasive,relatively safe advantage. This paper reviews the progression of sonodynamic treatment on cerebral AS.

关 键 词：声动力疗法 脑动脉粥样硬化 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R445.1[医药卫生—临床医学]