前列腺癌神经内分泌分化研究新进展  

Advances in the researches of neuroendocrine differentiation in prostate cancer

作　　者：徐明[1] 梁朝朝[1] 邰胜[1] 

机构地区：[1]安徽医科大学第一附属医院泌尿外科,合肥230022

出　　处：《临床泌尿外科杂志》2015年第4期372-375,共4页Journal of Clinical Urology

基　　金：国家自然科学基金项目(编号81170698;81370856);安徽省科技攻关项目(编号12010402128)

摘　　要：虽做了大量研究,但激素依赖性前列腺癌转化为激素非依赖性前列腺癌的机制仍然不清。目前,研究显示前列腺癌组织内的神经内分泌分化现象与前列腺癌的发生、进展、雄激素非依赖性转化和临床不良预后等有重要关系。本文就前列腺神经内分泌分化的起源,对激素非依赖性的前列腺癌分子机制及预后意义进行综述。Although a lot of researches have been done, the mechanism of translation from hormone-dependent prostate cancer into hormone-independent prostate cancer is still unclear. At present, studies show that the phenomenon of neuroendocrine differentiation is associated with the occurrence, progression, androgen independent translation and clinical adverse prognosis of prostate cancer. In this article, we review the origin, molecular mechanism, prognostic and predictive significance of neuroendocrine differentiation in human prostate cancer.

关 键 词：前列腺癌 神经内分泌分化 

分 类 号：R737.25[医药卫生—肿瘤]