线粒体膜电位与海洛因海绵状白质脑病的关系  

Relationship between mitochondrial membrane potential and heroin spongiform leukoencephalopathy

作　　者：林敏仕[1] 周亮[2] 

机构地区：[1]广西医科大学附属钦州市第一人民医院神经内科,钦州535000 [2]南方医科大学南方医院神经内科,广州510515

出　　处：《神经解剖学杂志》2015年第2期193-196,共4页Chinese Journal of Neuroanatomy

基　　金：广东省科技基金(2012B031800472)

摘　　要：目的:探讨线粒体呼吸链膜电位与海洛因海绵状白质脑病的关系。方法:运用荧光探针JC-1对外周血细胞线粒体膜电位进行标记,再通过流式细胞仪检测海洛因海绵状白质脑病患者及正常组膜电位改变情况。结果:海洛因白质脑病组与正常组线粒体膜电位测定结果分别为0.24±0.07和0.18±0.05,两组间具有显著差异(P<0.01)。结论:急性期海洛因海绵状白质脑病患者线粒体膜电位活性较正常组明显下降,它是线粒体调亡信号,推测本病可能的发病机制是,烫吸过程中产生的毒物使海洛因海绵状白质脑病患者机体内细胞的线粒体功能发生了障碍,导致了乳酸的堆积,从而引起对缺氧敏感的颅内组织出现广泛的白质继发脱髓鞘。Objective： To examine the association between hroin spongiform leucoencephalopathy（ HSLE） and mitochondrial membrane potential（ MMP）. Methods： MMP was marked by JC-1,and the change of MMP detected by flow cytometry machine. Results： The indicators of detection were significant different between the two groups（ 0. 24 ± 0. 07 vs 0. 18 ± 0. 05,t = 4. 893,P 〈 0. 01）. Conclusion： The activity of MMP in HSLE is significantly decreased in normal group. It speculates HSLE have the disorder of mitochondrial function,and leading to lactic acid accumulation,and the secondary demyelination in white matter for hypoxia.

关 键 词：海洛因 白质脑病 线粒体 膜电位 

分 类 号：R741[医药卫生—神经病学与精神病学]