糖尿病视网膜病变患者血清apelin与血脂水平观察  

The correlational study between serum Apelin and blood lipid level in diabetic retinopathy

作　　者：程金涛[1] 戚金泽 梁佳美[1] 张庆芬[1] 

机构地区：[1]山东省临沂市沂水中心医院眼科,276400

出　　处：《中华眼底病杂志》2015年第2期139-142,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：山东省临沂市科技计划项目（201413035）

摘　　要：目的观察糖尿病视网膜病变（DR）患者血清apelin与血脂水平。方法临床检查确诊的2型糖尿病（T2DM）患者90例纳入研究。均行视力、裂隙灯显微镜、间接检眼镜、荧光素眼底血管造影检查。根据检查结果，按美国眼科学会DR临床分期标准，将患者分为无DR（NDR）组、非增生型DR（NPDR）组、增生型DR（PDR）组。每组均为30例。选择同期健康体检者30名作为对照组。4组受检者年龄（F=0．564），身高（F=0．332）、体重（F=0．336）、体重指数（F=0．297）比较，差异均无统计学意义（P〉0．05）。采用全自动生化分析仪测定受检者血清胆固醇（Tc）、甘油三酯（TG）、高密度脂蛋白（HDLC）、低密度脂蛋白（LDLC）、糖化血红蛋白（HbAlc）水平；酶联免疫吸附试验测定血清中apelin水平。HbA1c、TC、TG、HDLC、LDLC、apelin与DR严重程度的相关性行多因素相关分析；与DR分期行直线相关分析。结果NDR组、NPDR组、PDR组、对照组受检者血清HbAlC（F=403．06）、TC（F=5．45）、HDLC（F-4．27）、LDLC（F-4．90）、apelin（F=201．56）水平比较，差异均有统计学意义（P〈0．05）；血清TG水平比较，差异无统计学意义（F=2．19，P〉0．05）。NDR组、NPDR组、PDR组血清HbA1C、TC、LDLC、apelin水平较对照组显著性升高，差异有统计学意义（t=0．30、0．58、0．79，P〈0．05）；HDLC水平较对照组显著降低，差异有统计学意义（t=0．79，P〈0．01）。DR分期与HbA1c、LDLC、apelin显著相关（r=0．962、0．562、0．935，P〈0．05）；与HDLC的下降极显著相关（r=－0．753，P〈0．01）。Apelin与HbA1C、LDLC有极显著相关性（r=0．956、0．741，P〈0．01）；与HDLC呈负相关（r=－0．691，P〈0．01）。结论DR患者血清中apelin水平明显升高，并且与血糖、血脂代谢异常密切相关。Objective To investigate the role of apelin, glycosylated hemoglobin （HbAlc）, cholesterol （ TC）, triglyceride （TG） , High density lipoprotein cholesterol （ HDLC）, low density lipoprotein cholesterol （LDLC） in the development and progress of diabetic retinopathy （DR）. Methods The serum concentration of apelin, HbAlc, TC, TG, HDLC and LDLC were measured in 30 normal control subjects and 90 patients with type 2 diabetic mellitus, including 30 cases without DR （NDR）, 30 with non-proliferative DR （NPDR） ,30 with proliferative DR （PDR）. These data were analyzed by SPSS for windows 13.0. Results The serum concentration of apelin, HbAlc, TC, HDLC, LDLC were significantly higher in NDR, NPDR, PDR group than those in control group （F=403.06, 5.45, 4.27, 201.56, 4.90; P〈0.05）. The serum concentration of TG has no significantly difference （F= 2. 19,P〉0.05）. The serum concentration of apelin, HbAlc, TC, LDLC were significantly higher in NDR, NPDR, PDR group than those in control group （t= 0.30, 0.58, 0.79; P 〈 0.05）, the serum concentration of HDLC were significantly lower than those in control group （t = 0.79, P 〈 0.01）. There were significantly positive correlation between the progression of DR and the serum concentration of apelin, HbA1c, TC, LDLC（r= 0. 962, 0. 562, 0. 935; P〈0. 05）. There were significantly negative correlation between the progression of DR and the serum concentration of HDLC（r= -0. 753, P〈0.01）. There were correlation between apelin and HbA1c, LDLC and HDLC（r=0. 956,0. 741,-0. 691; P〈0.01）. Conclusion Our data demonstrated that serum apelin levels increased significantly in patients with diabetic retinopathy, and are closely related to blood sugar, blood lipid metabolic abnormalities.

关 键 词：糖尿病视网膜病变/病因学 血脂异常/代谢 脂肪因子类 

分 类 号：R774.1[医药卫生—眼科]