GM-CSF对兔血液动力性脑缺血后颅内侧支动脉生成的影响  

Effect of GM-CSF on collateral arteriogenesis of posterior cerebral circulation in rabbits with hemodynamic ischemia

作　　者：张桂运[1] 陈左权[2] 凌锋[3] 

机构地区：[1]同济大学附属同济医院神经外科,上海200065 [2]同济大学附属第十人民医院神经外科,上海200072 [3]首都医科大学附属宣武医院神经外科,北京100053

出　　处：《同济大学学报（医学版）》2015年第1期5-8,共4页Journal of Tongji University(Medical Science)

基　　金：国家自然科学基金(30872678)

摘　　要：目的研究粒-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)对兔后循环血液动力性脑缺血后侧支循环生成的影响。方法 40只新西兰大白兔随机分为对照组、假手术组、非治疗模型组、GM-CSF治疗模型组、生理盐水治疗模型组,每组8只。模型组均采用手术结扎右侧锁骨下动脉椎动脉开口近端。采用超选择脑血管造影及染色乳胶灌注法检测盗血及血管管径、血管密度及后分水岭区面积。结果GM-CSF治疗模型组颅内前循环动脉管径较非治疗模型组明显增粗(P<0.01),侧支血管密度明显增加。非治疗模型组颅内前循环动脉管径及侧支血管密度较对照组有所增加,但差异无统计学意义(P>0.01)。结论 GMCSF对兔后循环血液动力性脑缺血后侧支动脉的生成具有重要作用。Objective To investigate the effect of GM-CSF on collateral arteriogenesis of posterior cerebral circulation in rabbits with hemodynamic ischemia. Methods Forty NewZealand rabbits were randomly divided into five groups（ control group,sham operation group,model group,GM-CSF group and saline control group）. In all the groups except the control one,the right subclavian artery proximal to the orifice of vertebral artery was ligated. Results Compared to the control group,the diameters of resistant arteries in posterior watershed,posterior communicating arteries and posterior cerebral arteries were enlarged significantly as well as the vascular density in GM-CSF group; and partial resistant arteries in posterior watershed were transformed into conductive arteries. The similar results were seen in the model group,but there was no statistical significance compared to the control group. Conclusion GM-CSF exerts a positive effect on collateral arteriogenesis of posterior cerebral circulation in rabbits with hemodynamic ischemia.

关 键 词：粒-巨噬细胞集落刺激因子 侧支动脉 动脉生成 脑缺血 

分 类 号：R743.31[医药卫生—神经病学与精神病学]