Prefrontal dysfunction and a monkey model of schizophrenia  

作　　者：Ping Mao Ding Cui Xu-Dong Zhao Yuan-Ye Ma 

机构地区：[1]Kunming General Hospital of Chengdu Military Command [2]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences [3]Yunnan Key Laboratory of Primate Biomedical Research [4]Kunming Institute of Zoology, Chinese Academy of Sciences

出　　处：《Neuroscience Bulletin》2015年第2期235-241,共7页神经科学通报（英文版）

基　　金：supported by National Basic Research Development Program (973 program) of China (2012CB825500, 2011CB707800);National Natural Science Foundation of China (31271168, 91132307/H09, 61178051);Finnish-Chinese Joint Project of National Natural Science Foundation of China (813111172)

摘　　要：The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyI-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral .impairment might be a specific indicator of schizophrenia-related cognitive impairment.The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyI-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral .impairment might be a specific indicator of schizophrenia-related cognitive impairment.

关 键 词：prefrontal cortex SCHIZOPHRENIA monkey model 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]