Bmi-1和Mina53在大肠癌组织中的表达及意义  

Clinical significance of expression of Bmi-1 and Mina53 in colorectal carcinoma

作　　者：王满[1] 张创杰[1] 徐峰[1] 赵立群[1] 

机构地区：[1]郑州大学第一附属医院消化内科,河南省郑州市450052

出　　处：《世界华人消化杂志》2015年第9期1420-1425,共6页World Chinese Journal of Digestology

摘　　要：目的:探讨Bmi-1(B-cell-specific moloney murine leukemia virus insertion site 1)和Mina53(myc-induced nuclear antigen with a molecular mass of 53 k Da)在大肠癌(colorectal carcinoma,CRC)组织中的表达及临床病理意义.方法:采用免疫组织化学法分别检测56例CRC及相应癌旁正常大肠黏膜组织中Bmi-1和Mina53蛋白的表达,并分析两者的表达水平相关性及与临床病理因素的关系.结果:CRC及相应癌旁正常大肠黏膜组织中Bmi-1蛋白的阳性表达率分别为80.4%和35.7%,M i n a53蛋白的阳性表达率分别为73.2%和19.6%,组间相比差异均有统计学意义(χ2=22.913、32.308,均P<0.05).CRC组织中Bmi-1和Mina53蛋白的表达与患者的性别、年龄无关(均P>0.05),而与肿瘤的分化程度、淋巴转移及浸润深度有关(均P<0.05).CRC组织中Bmi-1和Mina53蛋白的表达呈正关联(r=0.296,P<0.05).结论:Bmi-1和Mina53的高表达可能与CRC的发生、发展及预后有关,联合检测两者对CRC的诊断及预后判断可能具有重要意义.AIM：To investigate the clinicopathological significance of expression of B-cell-specific moloney murine leukemia virus insertion site1（Bmi-l） and myc-induced nuclear antigen with a molecular mass of 53 kDa（Mina53） in colorectal carcinoma.METHODS：The expression of Bmi-l and Mina53 proteins was detected by immunohistochemistry in 56 colorectal cancer samples and matched tumor-adjacent normal tissue samples.The correlation between the expression of these proteins and the clinicopathologic features of colorectal carcinoma was analyzed.RESULTS：The positive rates of Bmi-1expression and Mina53 in colorectal cancer were significantly higher than those in matched tumor-adjacent normal tissue（80.4%vs 35.7%,73.2%vs 19.6%,χ^2= 22.913,32.308,P〈 0.05 for both）.Expression of Bmi-1 and Mina53 was significantly associated with tumor differentiation,lymph node metastasis and tumor infiltration depth in colorectal carcinoma（P 0.05 for all）,but not with age or gender（P〈 0.05 for both）.A positive correlation was noted between the expression of Bmi-1 and that of Mina53 in colorectal carcinoma（r = 0.296,P 〉0.05）.CONCLUSION：High expression of Bmi-1and Mina53 proteins may participate in the occurrence,progression and prognosis of colorectal carcinoma.Combined detection of the expression of these proteins is helpful to the diagnosis and evaluation of the prognosis of colorectal carcinoma.

关 键 词：大肠癌 BMI-1 MINA53 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]