化疗栓塞联合射频消融治疗肝癌的疗效及对患者BDNF水平的影响  

Transcatheter hepatic arterial chemoembolization in combination with radiofrequency ablation for treatment of patients with hepatocellular carcinoma: Curative efficacy and effect on serum BDNF level

作　　者：屈小勇[1] 秦春宏[1] 吴江[1] 陈召良[1] 杨文军[1] 

机构地区：[1]南华大学附属第二医院普外科,湖南省衡阳市421001

出　　处：《世界华人消化杂志》2015年第9期1473-1478,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81172365~~

摘　　要：目的:探讨肝动脉化疗栓塞(transcatheter hepatic arterial chemoembolization,TACE)联合射频消融(radiofrequency ablation,RFA)治疗肝癌疗效、不良反应及对患者血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)的影响,为肝癌的临床治疗提供依据.方法:收集南华大学附属第二医院于2012-02/2014-02收治的100例肝癌患者,随机分为对照组50例与观察组50例.对照组给予TACE治疗,观察组在常规治疗基础上给予联合RFA治疗,观察并比较两组患者疗效、不良反应及对患者血清BDNF水平的影响.结果:观察组患者治疗有效率达86.0%,显著高于对照组患者的62.0%,差异具有统计学意义(P<0.05),观察组患者肿瘤完全坏死率显著高于对照组(62%vs 24%),其肿瘤复发率显著低于对照组(24%vs 54%),差异均有统计学意义(P<0.05).观察组患者除头痛、发热的发生率高于对照组外,其余不良反应与对照组比较差异无统计学意义(P>0.05);两组治疗后血清BDNF水平与治疗前相比,均有明显降低(P<0.05);且与对照组相比,观察组治疗后血清BDNF水平低于对照组,差异有统计学意义(P<0.05).结论:TACE联合RFA治疗肝癌疗效确切,不良反应并无明显增加,安全性较好,并且可显著降低患者血清BDNF水平,值得临床上进一步研究.AIM：To investigate the curative efficacy of transcatheter hepatic arterial chemoembolization（TACE） in combination with radiofrequency ablation（RFA） in the treatment of patients with hepatocellular carcinoma（HCC） and the effect on the level of brain-derived neurotrophic factor（BDNF）.METHODS：One hundred HCC patients treated at the Second Affiliated Hospital of University of South China were randomly divided into two groups equally：a control group and an observation group.The control group（CG） was treated by TACE alone,and the observation group（OG） was treated by TACE in combination with RFA.The curative efficacy,tumor necrosis rate,recurrence rate,side effects and the level of BDNF in serum were compared for the two groups.RESULTS：The curative efficacy and tumor necrosis rate were both significantly higher in the OG group than in the CG group（86.0%vs 62%,54%vs 24%,P〈0.05）.The recurrence rate was also significantly higher in the OG group（24%vs 54%,P〈0.05）.The rates of side effects between the two groups had no significant difference（P〈0.05） except for headache and fever,the rates of which were both significantly higher in the OG group（P〉0.05）.Serum levels of BDNF in the two groups after treatment were both significantly lower than those before treatment（P〈0.05）.The level of BDNF in the OG group was significantly lower than that in the CG group after treatments（P〈0.05）.CONCLUSION：Combined TACE and RFA for HCC therapy is effective and safe,and can significantly decrease serum BDNF level.

关 键 词：肝动脉化疗栓塞 射频消融 肝癌 脑源性神经营养因子 

分 类 号：R735.7[医药卫生—肿瘤]