难治性颞叶癫痫患者术后生活质量分析  

Life Quality Analysis of Intractable Temporal Lobe Epilepsy Patients after Surgery

作　　者：刘晓艳[1] 康慧聪[1] 胡琦[1] 许峰[1] 梁奇明[1] 连立飞[1] 朱遂强[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030

出　　处：《神经损伤与功能重建》2015年第2期122-124,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:评估难治性颞叶癫痫术后患者的生活质量。方法:随访行手术治疗的难治性颞叶癫痫患者34例,分别于术前1月、术后6月、术后12月应用癫痫患者生活质量量表-31(QOLIE-31)中文版对患者生活质量进行评估;术后疗效根据Engle分级标准分为2组:满意组(EngleⅠ和Ⅱ级)和不满意组(EngleⅢ和Ⅳ级),比较2组生活质量。结果:术后6月随访,疗效满意23例(满意组),不满意11例(不满意组),满意组术后生活质量各方面均明显改善(P<0.05),且在发作担忧、情感幸福、社会功能和总体生活质量方面改善优于不满意组(P<0.05);不满意组术后生活质量也较术前改善(P<0.05),药物副作用差异无统计学意义(P=0.255)。术后12月随访,疗效满意27例(满意组),不满意7例(不满意组),不满意组患者生活质量术后保持稳定,满意组生活质量仍明显改善,且各方面改善程度均较不满意组明显(P<0.05)。结论:难治性颞叶癫痫手术可以改善术后早期的生活质量,生活质量的持续改善则与手术疗效密切相关。Objective： To evaluate the life quality of intractable temporal lobe epilepsy（TLE） patients after the surgery. Methods： Thirty-four intractable TLE patients undergoing epilepsy surgery were enrolled. Quality of life（QOL） was measured by the Quality of Life in Epilepsy Inventory-31（QOLIE-31） before surgery, 6 months, and 12 months after surgery. Seizure outcome was assessed using Engle grading. Patients were divided into two groups according to surgery outcome： good outcome group（EngleⅠandⅡ） and poor outcome group（EngleⅢand Ⅳ）.Results： At the 6-month follow-up, there was significant improvement in all the domains of QOLIE-31 in the good outcome group（23 cases） after surgery（P〈0.05）. QOL improvement was seen in all the domains in the poor outcome group（11 cases） except medication effects（P=0.255）. At the 12-month follow-up, QOL continued to improve in the good outcome group（27 cases） and stabilized in the poor outcome group（7 cases）. QOL was significantly better in the good outcome group than that in the poor outcome group（P〈0.05）. Conclusion： After temporal resection, QOL improves in the good outcome group while QOL in the poor outcome group stabilizes.These results may be useful in pre-surgical counseling and identifying patients at risk for poor psychosocial outcome following surgery.

关 键 词：难治性颞叶癫痫 生活质量 手术疗效 

分 类 号：R741[医药卫生—神经病学与精神病学] R742.1[医药卫生—临床医学]