牙周致病微生物与药物性牙龈肥大的关系  

Relationship between Periodontal Pathogens and Drug-induced Gingival Enlargement.

作　　者：刘海杰[1] 潘亚萍[1,2] 

机构地区：[1]中国医科大学口腔医学院牙周科,辽宁沈阳110002 [2]辽宁省口腔医学研究所牙周病学研究室

出　　处：《口腔医学研究》2015年第4期370-372,376,共4页Journal of Oral Science Research

基　　金：国家自然科学基金项目(编号:81271153)

摘　　要：目的:探讨菌斑微生物在硝苯地平诱导的药物性牙龈肥大中的作用。方法:采用Real-time PCR技术对服用硝苯地平后出现药物性牙龈肥大的高血压患者(A组,23例)、服用硝苯地平后未出现药物性牙龈肥大的高血压患者(B组,23例)、慢性牙周炎者(C组,23例)龈下菌斑内牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)、中间普氏菌(Prevotella intermedia,Pi)、齿垢密螺旋体(Treponema denticola,Td)和福赛坦氏菌(Tannerella forsythia,Tf)进行相对定量检测,比较3组患者龈下菌斑中4种牙周致病微生物相对含量的差异。结果:Pg、Td、Tf、Pi在A组明显高于B组,两者之间有统计学差异(P<0.05),A组与C组比较无统计学差异。结论:菌斑微生物在硝苯地平诱导的药物性牙龈肥大中起着重要作用。Objective：To investigate the role of periodontal pathogens in nifedipine-induced gingival enlargement.Methods：The differences of relative quantification of periodontal pathogens including porphyromonas gingivalis（Pg）,prevotella intermedia（Pi）,treponema denticola（Td）,tannerella forsythia（Tf）were tested in hypertension patients with nifedipine-induced gingival enlargement（Group A,23cases）,hypertension patients taking nifedipine without nifedipine-induced gingival enlargement（Group B,23cases）,patients with chronic periodontitis（Group C,23cases）using real-time PCR.Results：The relative quantification of Pg、Td、Tf and Pi between Group A and Group B had statistically difference（P〈0.05）,Group A was higher than Group B,but had no statistical difference between Group A and Group C.Conclusion：Plaque microorganisms play a very important role in nifedipine-induced gingival enlargement.

关 键 词：药物性牙龈肥大 牙周致病菌 硝苯地平 

分 类 号：R781.4[医药卫生—口腔医学]