Hedgehog信号通路效应蛋白在舌癌组织中的表达及意义  

Expression and Signification of Hedgehog Signaling Pathway Effective Proteins in the Tongue Carcinoma and Paracarcinoma Tissues.

作　　者：孙国文[1,2] 张笑佛 李田[1,2] 胡勤刚[1,2] 唐恩溢[1,2] 

机构地区：[1]南京市口腔医院 [2]南京大学医学院附属口腔医院口腔颌面外科,江苏南京210008

出　　处：《口腔医学研究》2015年第4期393-396,共4页Journal of Oral Science Research

基　　金：江苏省自然科学基金课题项目(编号:BK2011102);江苏省临床医学科技专项项目(编号:BL2012017;BL2013005);江苏省卫生厅课题项目(编号:H201441)

摘　　要：目的:探讨Hedgehog(HH)信号通路中效应蛋白Ptch、Smo和Gli1在舌癌、癌旁组织中的表达及意义。方法:采用免疫组织化学方法检测我院24例舌癌患者的病灶及癌旁组织中Ptch、Smo和Gli1的表达。结果:Ptch和Smo在舌癌组织中为高表达,与患者年龄、性别、烟酒习惯等不相关,而与组织学分级、临床分期有相关性,在组织学分级和临床分期越高的舌癌组织中表达越高。部分Ptch及Smo阳性表达的舌癌组织中,Gli1也呈阳性表达。结论:HH信号通路可通过Ptch和Smo的过度表达,有可能通过进一步激活转录因子Gli1及其他目的基因,与舌癌的发生及发展存在一定关系。Objective：To investigate the expression and significance of the Ptch,Smo and Gli1 expression of Hedgehog（HH）signaling pathway proteins in tongue carcinoma and paracarcinoma tissues.Methods：Using the immunohistochemical method,the expression of Ptch,Smo and Gli1 in the 24 tissue samples with tongue carcinoma and paracarcinoma tissues was analysed.Results：The expression of Ptch and Smo was positive in most of tongue carcinoma tissues.Their expressions had no relations with the patients＇ age,sex,smoking and drinking habits,and had the positive correlation with the clinical stage and histological grading.In some cases of tongue carcinoma of the positive expression of Ptch and Smo,the Gli1 showed the positive expression.Conclusion：The HH signaling pathways by overexpression of Ptch and Smo further activate gene transcription factors gli1 and other target gene.The occurrence and development of tongue carcinoma has a certain relationship with the HH signaling pathways.

关 键 词：舌癌 HH信号通路 PTCH SMO GLI1 

分 类 号：R739.86[医药卫生—肿瘤]