Beclin 1在凋亡和自噬中的调节作用  

Beclin 1 Regulates Apoptosis and Autophagy

作　　者：张雨晴 张丽慧[1] 魏尔清[2] 杨怡[1] 

机构地区：[1]杭州师范大学医学院药理教研室,杭州310036 [2]浙江大学医学院药理学系,杭州310058

出　　处：《中国生物化学与分子生物学报》2015年第4期331-338,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81401043,No.81273491);浙江省自然科学基金(No.LQ13H310004,No.LY12H31010);浙江省医药卫生一般研究计划(No.2013KYA147);杭州市重点实验室项目(No.20090233T12);杭州师范大学科研启动经费项目(No.2012QDL048)~~

摘　　要：Beclin 1是自噬关键调控蛋白之一,参与自噬体膜形成.近期,大量研究结果指出,Beclin 1是caspase家族蛋白酶的全新底物,可被caspase剪切.剪切后的Beclin 1失去自噬调节功能,转而加剧凋亡进程.因而,Beclin 1对细胞凋亡和自噬起着重要的调控作用.本文主要对细胞凋亡和自噬的相关性,以及Beclin 1在两通路中的调控作用进行了回顾与总结.在此基础上,进一步讨论了Beclin 1与人类疾病如肿瘤、神经系统退行性疾病的关联.最后,简要介绍了实验室常用于Beclin 1研究的工具.Beclin 1,as a crucial regulatory protein,regulates autophagosome membrane formation.Recently,the accumulated evidence suggests that Beclin 1 is a novel substrate of caspase family members and can be cleaved by caspases.Cleaved Beclin 1 can not trigger autophagic activation,but promotes apoptosis.Therefore,Beclin 1 plays an essential role in regulating apoptosis and autophagy.In this study,we summarized the recent advances in the association between apoptosis and autophagy,as well as the regulatory effects of Beclin 1 in mediating apoptosis and autophagy.In addition,we discussed the link between Beclin 1 and human diseases（e.g.cancer and neurodegenerative disorders）.Finally,the commonly used tools for the study of Beclin 1 in laboratory were briefly introduced.

关 键 词：BECLIN 1 自噬 凋亡 肿瘤 神经系统退行性疾病 

分 类 号：R34[医药卫生—基础医学]