急性脊髓损伤后的炎症反应及其抗炎治疗  

Inflammatory response and anti-inflammatory therapy after acute spinal cord injury

作　　者：王涛丽 顾兵[1] 李华南[2] 张国福[2] 张思[1] 

机构地区：[1]江西科技师范大学生命科学学院,江西南昌330013 [2]江西中医药大学附属医院脊柱外科,江西南昌330006

出　　处：《中国药理学通报》2015年第4期452-457,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 30960448);江西省自然科学基金资助项目(No 20142BAB205023);江西省教育厅科学技术研究项目(No GJJ12584;GJJ14603)

摘　　要：急性脊髓损伤可导致严重的运动、感觉和括约肌功能障碍。由炎症因子引起的炎症反应在继发性损伤的发生、发展过程中起关键作用。通过恰当的抗炎干预维持机体致炎/抗炎平衡,将成为脊髓损伤药物治疗的一条重要策略。该文主要介绍炎症反应的产生原因、作用过程以及参与急性脊髓损伤的病理生理机制,并综述抗炎药物实验研究的最新进展,旨在为寻找安全有效的药物提供参考依据。Acute spinal cord injury can lead to severe motor,sensory and sphincter muscle dysfunction. Inflammatory response caused by inflammatory cytokines plays a crucial role in the occurrence and development of secondary damage. Maintaining the body balance between inflammaion and anti-inflammation through an appropriate anti-inflammatory intervention will be an important strategy for drug therapy of spinal cord injury. This paper mainly introduces the cause,process and participation of inflammatory response in the pathophysiological mechanism of acute spinal cord injury,and also reviews the latest progress of experimental research of anti-inflammatory drugs,aiming to provide reference for finding the safe and effective drugs.

关 键 词：脊髓损伤 继发性损伤 炎症反应 抗炎治疗 甲基强的松龙 米诺环素 

分 类 号：R05[医药卫生] R364.5