97例鼻腔NK/T细胞淋巴瘤治疗方案及预后相关因素分析  

Analysis of Treatment Protocols and Prognostic Factors of 97Patients with Nasal NK/T Cell Lymphoma

作　　者：于珊珊[1] 艾丽梅[1] 向蕾[1] 潘静[1] 张欣[2] 

机构地区：[1]辽宁医学院附属第一医院血液科,辽宁锦州121001 [2]辽宁医学院附属第一医院核医学科,辽宁锦州121001

出　　处：《医学与哲学（B）》2015年第3期28-31,共4页Medicine & Philosophy(B)

基　　金：辽宁省科技厅自然基金项目;项目编号:201202136;2014022007

摘　　要：探讨不同治疗方案对鼻腔NK/T细胞淋巴瘤缓解率和生存时间的影响,以及影响预后的多种相关因素。结果显示,在对于原发于鼻腔NK/T细胞淋巴瘤治疗方案的选择上,单独接受放疗及放化疗联合治疗的效果要明显优于单独接受化疗治疗的患者。对于接受化疗治疗的患者,为提高生存率应尽量选择以左旋门冬酰胺酶为主的化疗方案。其治疗方案、乳酸脱氢酶水平、临床分期是与预后相关的独立因素,而首次化疗后缓解率、有无B症状则与预后无关。This thesis aims to study the influence of different treatment protocols on remission rate and survival time of nasal NK /T cell lymphoma and various prognostic factors . The result indicated that the effect of radiotherapy alone and chemoradiation is significantly better than that of chemotherapy alone with respect to choosing protocols for primary nasal NK /T cell lymphoma .In order to improve survival rate of the patients receiving chemotherapy ,it is advised to treat them mainly with L‐Asparaginase . The protocols , lactate dehydrogenase levels and clinical staging are independent factors related to prognosis ,while the remission rate after the first chemotherapy and whether the symptom B exists or not are irrelevant to prognosis .

关 键 词：NK/T细胞淋巴瘤 治疗方案 预后因素 

分 类 号：R733.4[医药卫生—肿瘤] R739.63[医药卫生—临床医学]