HE4在子宫内膜癌患者血清中的表达及其与各临床病理参数的关系  

Expression of HE4 in serum of patients with endometrial carcinoma and its relation with different clinicopathological parameters

作　　者：杨胜晗[1] 王蕾香[1] 韩春薇[1] 

机构地区：[1]安徽省蚌埠市第三人民医院妇产科,233000

出　　处：《淮海医药》2015年第3期230-232,共3页Journal of Huaihai Medicine

摘　　要：目的通过检测正常子宫内膜、子宫内膜不典型增生、子宫内膜癌患者血清HE4表达情况,分析HE4与子宫内膜癌各临床病理参数间的关系,探讨HE4在子宫内膜癌发生发展中的作用。方法用化学发光微粒子免疫分析法（CMIA）检测15例正常子宫内膜患者,10例子宫内膜不典型增生患者及40例子宫内膜癌患者血清中HE4的表达情况。结果正常子宫内膜组血清HE4范围为（27.7-84.0）pmol/L,均值为（40.3±16.2）pmol/L;子宫内膜不典型增生组血清HE4范围为（41-83）pmol/L,均值为（54.7±18.5）pmol/L;子宫内膜癌组血清HE4范围为（33.9-1040.9）pmol/L,均值为（120.2±195.6）pmol/L。子宫内膜癌组HE4水平明显较正常子宫内膜组高（Z=-3.444,P=0.01〈0.05）;血清HE4水平与子宫内膜癌患者的年龄、组织分级及病理类型无关（Z=-1.671,P=0.095〉0.05;Z=-1.569,P=0.117〉0.05;Z=-1.155,P=0.248〉0.05）;而与手术-病理分期、肌层浸润深度及淋巴结转移密切相关（P〈0.05）。子宫内膜癌的期别越晚,血清HE4水平越高,Ⅰ-Ⅱ期患者血清HE4水平明显低于Ⅲ-Ⅳ期患者（Z=-2.583,P=0.010〈0.05）;深肌层浸润的患者血清HE4水平明显高于浅肌层浸润的患者（Z=-2.500,P=0.012〈0.05）。有淋巴结转移的患者血清HE4水平明显高于无淋巴结转移的患者（Z=-3.088,P=0.002〈0.05）。结论血清HE4水平在正常子宫内膜、子宫内膜不典型增生、子宫内膜癌患者血清中表达逐渐升高,因此HE4可能与子宫内膜癌的发生、发展有关。Objective To analyze the relationship between levels of serum HE4 and different clinicopathological parameters of endometrial carcinoma and explore the role of HE4 in the occurrence and development of endometrial cancer. Methods Serum levels of HE4 were tested by an chemiluminescent microparticle immunoassay（ CMIA） method. 65 patients were divided as follows： 15 cases of normal endometrium,10 cases of endometrial atypical hyperplasia,and 40 cases of endometrial carcinoma. Results The range of serum HE4 levels in the normal endometrium group were 27. 7 - 84. 0pmol / L,with an average of 40. 3 ± 16. 2pmol / L; 41 - 83 pmol / L in the endometrial atypical hyperplasia group,with an average of 54. 7 ±18. 5pmol / L; and 33. 9 - 1 040. 9pmol / L in the endometrial cancer group,with an average of 120. 2 ± 195. 6pmol / L. The levels of HE4 in EC group were significantly higher than those in the normal endometrium group,with a significant difference（ Z =-3. 444,P = 0. 01 〈0. 05）. The levels of serum HE4 of patients with endometrial cancer were not correlated with ages,histological grades and pathological types（ Z =- 1. 671,P = 0. 095〉 0. 05; Z =- 1. 569,P = 0. 117 〉0. 05; Z =- 1. 155,P = 0. 248 〉0. 05）,while it had positive correlation with surgical-pathologic stage,depth of myometrial invasion and lymph node metastasis（ P〈0. 05）. The later,the higher levels of serum HE4 in EC were. The levels of serum HE4 in patients of EC with clinical stage Ⅲ-Ⅳ were higher than those of the patients of EC with clinical stageⅠ-Ⅱ（ Z =- 2. 583,P = 0. 010 〈0. 05）. The levels of serum HE4 in patients of EC with deep myometrial invasion were significantly higher than those of the patients of EC with superficial myometrial invasion（ Z =- 2. 500,P = 0. 012 〈0. 05）. The levels of serum HE4 in patients of EC with lymph node metastasis were significantly higher than those of the patients of EC with non lymph node metastasis（ Z =- 3. 088,P = 0. 002 〈0. 05）. Conclusion The expressions of serum

关 键 词：子宫内膜肿瘤 人附睾蛋白4 化学发光微粒子免疫分析法 肿瘤标记 生物学 

分 类 号：R737.33[医药卫生—肿瘤]