伽玛刀配合注射用核糖核酸Ⅱ治疗中晚期非小细胞肺癌42例临床观察  

Clinical observation of 42 cases with middle-late stage non-small cell lung cancer by Gamma knife with RNA Ⅱ for injection treating

作　　者：任朝英[1] 贾漪涛[1] 赵武杰[1] 李亚星[1] 王斌[1] 

机构地区：[1]河北省人民医院肿瘤三科,河北石家庄050051

出　　处：《医药前沿》2015年第6期24-25,共2页Journal of Frontiers of Medicine

摘　　要：目的：探讨分析伽玛刀配合注射用核糖核酸Ⅱ对于中晚期非小细胞肺癌的临床治疗效果。方法：选取我院2012年1月-2013年7月期间确诊收治入院的42例中晚期非小细胞肺癌患者，以随机方式将其分为两组，观察组患者使用伽玛刀配合注射用核糖核酸Ⅱ进行治疗，对照组患者仅使用伽玛刀进行治疗，比较分析两组患者临床治疗效果及不良反应情况。结果观察组21例中，CR2例，PR18例，NC1例，总有效率95．2％。对照组21例中，CR2例，PR17例，NC2例，总有效率90．5％，二者对比差异无统计学意义（P〉0．05）；观察组恶心、食欲不振3例，白细胞及血小板下降5例，均为Ⅰ度不良反应。对照组恶心、食欲不振8例，白细胞及血小板下降8例，其中Ⅰ度不良反应6例，Ⅱ度不良反应2例。两组患者不良反应对比差异明显，在统计学上有意义（P〈0．05）。结论：伽玛刀配合使用注射用核糖核酸，可明显减轻不良反应，有效改善患者对放疗的耐受性，提高生活质量，值得在临床上广泛使用。Objective Gamma knife are discussed with ribonudeic acid for injection Ⅱfor locally advanced non-small cell lung cancer dinical therapeutic effect. Methods Selected from January 2012 - July 2013 confirmed admitted during the period of 42 patients with locally advanced non-smaU cell lung cancer, it can be divided into 2 groups in random way, observation group of patients using gamma knife with ribonucleic acid for injection Ⅱ treatment, control group patients use only the gamma knife treatment, compared two groups of patients with clinical therapeutic effects and adverse reactions. Results Observation group of nausea, loss of appetite （3 cases）, white blood cells and platelets decreased in 5 cases, adverse reactions are Ⅰ degrees. Control of nausea, loss of appetite, 8 cases ofwhite cells and platelets by 8 cases. Clear difference conwast, statistically significant （P 〈 0.05）. Conclusions Gamma knife used ribonudeic acid for injection Ⅱ ; can significantly reduce adverse reaction, effectively improve patients tolerance to radiation therapy, improve the quality of life, is widely used in dinic.

关 键 词：伽玛刀 核糖核酸Ⅱ 非小细胞肺癌 

分 类 号：R730[医药卫生—肿瘤]