小细胞肺癌研究新视野——循环肿瘤细胞的临床应用价值  

New prospect for study on small cell lung cancer: implication of clinical application of circulating tumor cells

作　　者：柳菁菁[1] 丁宇霜 张爽[1] 程颖[1] 

机构地区：[1]吉林省肿瘤医院胸部肿瘤内科,吉林长春130012 [2]吉林大学第二医院肿瘤科,吉林长春130041

出　　处：《肿瘤》2015年第4期461-466,共6页Tumor

基　　金：吉林省科技发展计划项目(编号:20110452);吉林省卫生计生科研计划项目(编号:2014Z014)~~

摘　　要：由于能够接受手术的小细胞肺癌(small cell lung cancer,SCLC)患者非常少,肿瘤标本取材困难,极大地限制了通过肿瘤组织对SCLC生物标志物进行研究。随着精准检测技术的发展,"液态活检"为SCLC的生物标志物研究带来了希望。循环肿瘤细胞(circulating tumor cells,CTCs)作为一种可替代肿瘤组织的液态标本,在SCLC患者外周血中高频率出现且含量丰富。近年来开展了多项SCLC患者CTCs相关研究,发现CTCs对SCLC的诊断和分期,监测复发和转移,评估疗效、预后以及个体化治疗等具有重要意义。本文对CTCs在SCLC中的检测、临床应用及个体化治疗中的探索方向进行综述。In consideration of a few patients with small cell lung cancer（SCLC）receiving surgery, it is diffcult to obtain tumor samples, extremely restricting biomarker research by SCLC tissue samples. With the development of precise measurement techniques, liquid biopsy brings hope for SCLC biomarker research. As an alternative tumor tissue,circulating tumor cells（CTCs） are found frequently and abundant in peripheral blood of patients with SCLC. Related CTCs studies which conducted in patients with SCLC in recent years have found that CTCs have great significance in diagnosis and staging of SCLC, recurrence and metastasis monitoring, evaluation of therapeutic effect and prognosis, and individualized treatment. This paper reviews the detection and clinical application of CTCs in SCLC and explores its implication in individualized treatment strategy for SCLC.

关 键 词：肺肿瘤 肿瘤循环细胞 预后 

分 类 号：R734.2[医药卫生—肿瘤]